Genetic Insights into Alzheimer's Disease
| Autor: | C. Dirk Keene, Katherine L. Lucot, Brenna Cholerton, Thomas J. Montine, Caitlin S. Latimer |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Aging Memory Dysfunction Amyloid business.industry Neurodegeneration Neuropsychology Cognition Progressive neurodegenerative disorder Disease medicine.disease Article Pathology and Forensic Medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Alzheimer Disease Clinical diagnosis Nerve Degeneration medicine Animals Humans business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Annu Rev Pathol |
| ISSN: | 1553-4014 1553-4006 |
| Popis: | Alzheimer's disease (AD) is a pervasive, relentlessly progressive neurodegenerative disorder that includes both hereditary and sporadic forms linked by common underlying neuropathologic changes and neuropsychological manifestations. While a clinical diagnosis is often made on the basis of initial memory dysfunction that progresses to involve multiple cognitive domains, definitive diagnosis requires autopsy examination of the brain to identify amyloid plaques and neurofibrillary degeneration. Over the past 100 years, there has been remarkable progress in our understanding of the underlying pathophysiologic processes, pathologic changes, and clinical phenotypes of AD, largely because genetic pathways that include but expand beyond amyloid processing have been uncovered. This review discusses the current state of understanding of the genetics of AD with a focus on how these advances are both shaping our understanding of the disease and informing novel avenues and approaches for development of potential therapeutic targets. |
| Databáze: | OpenAIRE |
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