Profiles of platelet volume distributions in normal individuals and in patients with acute leukemia
| Autor: | Benjamin Drewinko, Dennis A. Johnston, Shanti S. Agarwal, Pamela R. Roper, Jacque Austin |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Blood Platelets Male Sensitive index Population Statistics as Topic medicine Distribution (pharmacology) Humans In patient Platelet Mean platelet volume education education.field_of_study Acute leukemia Leukemia Chemistry business.industry General Medicine medicine.disease Blood Cell Count Immunology Acute Disease Female Nuclear medicine business |
| Zdroj: | American journal of clinical pathology. 68(4) |
| ISSN: | 0002-9173 |
| Popis: | Several investigations have demonstrated that human platelets contain subpopulations of heavy–large (young) elements that are hemostatically more effective than subpopulations of lighter–smaller (old) platelets. By means of a multichannel particle size discriminator the authors could visualize such platelet subpopulations and were able to monitor the fluctuations that occur within different volume compartments in patients with acute leukemia. The subjects for this study included 55 blood bank donors (27 male) and 17 untreated patients with acute leukemia. Platelet volume distribution profiles were obtained with a multichannel particle size analyzer (100 channels) attached to an electronic particle counter. Platelet volumes monitored in all channels were averaged into groups of ten compartments consisting of discrete increments of 2 μ m3 each, to yield a ten-dimensional vector profile for each subject. The mean platelet volume distribution profile of normal individuals was represented by a skewed curve. Platelet volumes ranged from 1 to 21 μ m3, with a median of 8.4 μ m3. Small platelets ( |
| Databáze: | OpenAIRE |
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