Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery
Autor: | Dávid Botond Hangyási, Akiva Elad, Fabien Bornert, Gerrit Sauer, Péter Windisch, Bernhard Hesse, Patrick Rider, Bálint Molnár, Emely L. Bortel, Daniel Rothamel, Željka Perić Kačarević, Drazen Tadic, Frank Witte |
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Přispěvatelé: | Nanomédecine Régénérative (NanoRegMed), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0303 health sciences
[SDV.BIO]Life Sciences [q-bio]/Biotechnology Barrier membrane Chemistry Magnesium Biomedical Engineering chemistry.chemical_element Soft tissue Sciences du Vivant [q-bio]/Biotechnologies 030206 dentistry Resorption Biomaterials 03 medical and health sciences 0302 clinical medicine Membrane Biodegradable Implant GBR Bone healing Soft tissue healing Bone regeneration Barrier function 030304 developmental biology Biotechnology Biomedical engineering Titanium |
Zdroj: | Bioactive Materials Bioactive Materials, KeAi Publishing, 2021, ⟨10.1016/j.bioactmat.2021.11.018⟩ |
ISSN: | 2452-199X |
Popis: | Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration (GBR) and are often made of resorbable collagen or non-resorbable materials such as PTFE. While collagen membranes do not provide sufficient mechanical protection of the covered bone defect, titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery. Thus, biodegradable GBR membranes made of pure magnesium might be an alternative. In this study a biodegradable pure magnesium (99.95%) membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective. After implantation, the magnesium membrane separates the regenerating bone from the overlying, faster proliferating soft tissue. During the initial healing period, the membrane maintained a barrier function and space provision, whilst retaining the positioning of the bone graft material within the defect space. As the magnesium metal corroded, it formed a salty corrosion layer and local gas cavities, both of which extended the functional lifespan of the membrane barrier capabilities. During the resorption of the magnesium metal and magnesium salts, it was observed that the membrane became surrounded and then replaced by new bone. After the membrane had completely resorbed, only healthy tissue remained. The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane. Overall, the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment. |
Databáze: | OpenAIRE |
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