Serum BDNF and cognitive dysfunction in SLE: findings from a cohort of 111 patients
| Autor: | Fabiano Ferreira Abrantes, Fernanda C Lopes, Helena Alessi, Paula C Coube, Lilia Alves Maria, Orlando Graziani Povoas Barsottini, Cristiane Kayser, Karina Hoshino, Lívia Almeida Dutra, Alexandre Wagner Silva de Souza |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Systemic lupus erythematosus medicine.diagnostic_test business.industry Brain-Derived Neurotrophic Factor Lupus Vasculitis Central Nervous System Cognition General Medicine medicine.disease Pathophysiology Rheumatology Cohort Studies Neurotrophic factors Internal medicine Potential biomarkers Cohort medicine Humans Lupus Erythematosus Systemic Cognitive Dysfunction Neuropsychological assessment skin and connective tissue diseases business |
| Zdroj: | Clinical Rheumatology. 41:421-428 |
| ISSN: | 1434-9949 0770-3198 |
| Popis: | The association between brain-derived neurotrophic factor (BDNF) and neuropsychiatric systemic lupus erythematosus (NPSLE) is controversial in the literature. Cognitive dysfunction (CD) is a common, underdiagnosed NPSLE manifestation, but its pathophysiology is unknown. Thus, we investigate serum BDNF as a potential biomarker of CD in a cohort of SLE patients.We included 63 SLE patients, 48 NPSLE, and 57 age- and gender-matched controls (CON). All participants underwent neuropsychological assessment. Data on cardiovascular comorbidities, SLE disease activity index (SLEDAI), and Systemic Lupus International Collaborating Clinics damage index (SLICC-DI) were compiled. Multiple regression analyses evaluated predictors of serum BDNF levels.Serum BDNF levels were lower in SLE and NPSLE patients than in CON (SLE 800.4 ± 502.7 vs. NPSLE 779.7 ± 426.3 vs. CON 1,345.5 ng/mL ± 438.4; p 0.001). In addition, hypertension (B: - 192.5, SE: 84.3, 95% CI: - 359.7 to - 25.3, p = 0.024) and SLICC-DI score (B: - 75.9, SE: 27.2, 95% CI: - 129.8 to - 22, p = 0.006) were predictors of serum BDNF levels in SLE. There was no relation between BDNF levels and CD.BDNF levels are lower in SLE patients than CON and inversely associated with hypertension and SLICC-DI scores. No association between BDNF levels and CD or NPSLE was observed in this cohort. These findings indicate that BDNF may be associated with overall burden in SLE rather than specific manifestations such as cognition impairment. Key Points • BDNF is associated with an overall burden in SLE rather than specific manifestations such as cognition dysfunction. • BDNF levels are reduced in patients with SLE, and higher SLICC-DI scores and hypertension are independent predictors of lower serum BDNF levels. • The cognitive dysfunction rate is elevated (46%) among Brazilian SLE patients. |
| Databáze: | OpenAIRE |
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