Development of a Simple Mechanical Screening Method for Predicting the Feedability of a Pharmaceutical FDM 3D Printing Filament

Autor: Muqdad Alhijjaj, Peter S. Belton, Sheng Qi, Jehad Nasereddin, Nikolaus Wellner
Rok vydání: 2018
Předmět:
Flexibility (anatomy)
Materials science
Drug Compounding
printability
Pharmaceutical Science
3D printing
fused deposition modeling 3D printing
plasticization
macromolecular substances
02 engineering and technology
030226 pharmacology & pharmacy
hot melt extrusion
Heating
Protein filament
03 medical and health sciences
solid dispersions
0302 clinical medicine
medicine
Deposition (phase transition)
Pharmacology (medical)
feedability screening
Composite material
Dosage Forms
Pharmacology
Principal Component Analysis
Reproducibility
Mechanical screening
business.industry
Organic Chemistry
Equipment Design
021001 nanoscience & nanotechnology
medicine.anatomical_structure
Printing
Three-Dimensional
Principal component analysis
Correlation analysis
Molecular Medicine
0210 nano-technology
business
Research Paper
Biotechnology
Zdroj: Pharmaceutical Research
ISSN: 1573-904X
0724-8741
Popis: Purpose The filament-based feeding mechanism employed by the majority of fused deposition modelling (FDM) 3D printers dictates that the materials must have very specific mechanical characteristics. Without a suitable mechanical profile, the filament can cause blockages in the printer. The purpose of this study was to develop a method to screen the mechanical properties of pharmaceutically-relevant, hot-melt extruded filaments to predetermine their suitability for FDM. Methods A texture analyzer was used to simulate the forces a filament is subjected to inside the printer. The texture analyzer produced a force-distance curve referred to as the flexibility profile. Principal Component Analysis and Correlation Analysis statistical methods were then used to compare the flexibility profiles of commercial filaments to in-house made filaments. Results Principal component analysis showed clearly separated clustering of filaments that suffer from mechanical defects versus filaments which are suitable for printing. Correlation scores likewise showed significantly greater values with feedable filaments than their mechanically deficient counterparts. Conclusion The screening method developed in this study showed, with statistical significance and reproducibility, the ability to predetermine the feedability of extruded filaments into an FDM printer. Electronic supplementary material The online version of this article (10.1007/s11095-018-2432-3) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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