Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment
| Autor: | Erwann Guénin, Anouchka Plan Sangnier, Romain Aufaure, Yoann Lalatonne, Claire Wilhelm, Laurence Motte |
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| Přispěvatelé: | Matière et Systèmes Complexes (MSC (UMR_7057)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Transformation Intégrée de la Matière Renouvelable (TIMR), Université de Technologie de Compiègne (UTC), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2018 |
| Předmět: |
Drug
bisphosphonate Letter media_common.quotation_subject General Physics and Astronomy Nanoparticle [CHIM.THER]Chemical Sciences/Medicinal Chemistry 02 engineering and technology lcsh:Chemical technology 010402 general chemistry lcsh:Technology 01 natural sciences cancer treatment Prostate cancer medicine Nanotechnology lcsh:TP1-1185 General Materials Science Electrical and Electronic Engineering lcsh:Science media_common lcsh:T photothermia Chemistry alendronate [CHIM.MATE]Chemical Sciences/Material chemistry Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease Combinatorial chemistry lcsh:QC1-999 In vitro 3. Good health 0104 chemical sciences Cancer treatment Nanoscience Colloidal gold gold nanoparticles Drug delivery lcsh:Q 0210 nano-technology lcsh:Physics |
| Zdroj: | Beilstein Journal of Nanotechnology Beilstein Journal of Nanotechnology, Karlsruhe Institute of Technology., 2018, 9, pp.2947-2952. ⟨10.3762/bjnano.9.273⟩ Beilstein Journal of Nanotechnology, Vol 9, Iss 1, Pp 2947-2952 (2018) |
| ISSN: | 2190-4286 |
| DOI: | 10.3762/bjnano.9.273 |
| Popis: | A gold therapeutic nanoplatform with the same molecule used as reductant, coating and therapeutic agent has been developed in a one-pot, one-phase process using alendronate, a drug from the bisphosphonate family known for its antitumor effects. In addition, the core made of gold nanoparticles (NPs) brings thermal functionalities under irradiation within the first biological window (650–900 nm). The Au@alendronate nanoplatform thus provided a combined antitumor activity through drug delivery and photothermal therapy. Au@alendronate NPs inhibited in vitro the proliferation of prostate cancer cells (PC3) in a dose-dependent manner, with an IC50 value of 100 µM. Under NIR irradiation a temperature increase was observed leading to a reduction of the IC50 value to 1 µM, with total tumor cell death at 100 µM. |
| Databáze: | OpenAIRE |
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