Pharmacodynamic effects of cinacalcet after kidney transplantation: once- versus twice-daily dose
| Autor: | Luciana Spataru, Laurence Lavayssière, Nassim Kamar, Lionel Rostaing, Dominique Durand, Laure Esposito, Isabelle Gennero, Olivier Cointault, Joelle Guitard, Peggy Gandia |
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| Přispěvatelé: | Service de Néphrologie - Hypertension Artérielle Dialyse - Transplantation, CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biochimie [Purpan], Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut Fédératif de Biologie (IFB) - Hôpital Purpan, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], Centre de Physiopathologie Toulouse Purpan (CPTP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Pharmacocinétique et de Toxicologie clinique [Toulouse], Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biochimie [CHU Toulouse], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Laboratoire Pharmacocinétique et de Toxicologie [CHU Toulouse], Simon, Marie Francoise |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Cinacalcet 030232 urology & nephrology Parathyroid hormone 030204 cardiovascular system & hematology MESH: Cyclosporine MESH: Kidney Transplantation MESH: Dose-Response Relationship Drug 0302 clinical medicine Longitudinal Studies Prospective Studies MESH: Longitudinal Studies MESH: Phosphorus Kidney transplantation MESH: Aged MESH: Middle Aged Phosphorus MESH: Naphthalenes Middle Aged MESH: Hyperparathyroidism Secondary 3. Good health MESH: Parathyroid Hormone Parathyroid Hormone Nephrology MESH: Kidney Failure Chronic MESH: Calcium Cyclosporine Female medicine.drug Adult medicine.medical_specialty Hypercalcaemia Urology Renal function Naphthalenes Tacrolimus MESH: Hypercalcemia 03 medical and health sciences Internal medicine medicine MESH: Tacrolimus Humans Aged Calcium metabolism Transplantation Hyperparathyroidism MESH: Humans Dose-Response Relationship Drug business.industry MESH: Adult medicine.disease Kidney Transplantation MESH: Male MESH: Prospective Studies Endocrinology Hypercalcemia Kidney Failure Chronic Calcium Hyperparathyroidism Secondary business MESH: Female Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation Nephrology Dialysis Transplantation, Oxford University Press (OUP), 2008, 23 (11), pp.3720-6. ⟨10.1093/ndt/gfn345⟩ Nephrology Dialysis Transplantation, 2008, 23 (11), pp.3720-6. ⟨10.1093/ndt/gfn345⟩ |
| ISSN: | 0931-0509 1460-2385 |
| DOI: | 10.1093/ndt/gfn345⟩ |
| Popis: | International audience; BACKGROUND: In the setting of kidney transplantation, cinacalcet has been given, mainly, once daily, but also twice daily. The aims of this prospective study were to assess the acute pharmacodynamic effect of cinacalcet administrated once or twice daily to kidney transplant patients with normal renal function and persisting hypercalcaemia due to hyperparathyroidism and to evaluate 1-year efficacy and tolerance of cinacalcet given at a dose of 30 mg b.i.d. METHODS: Eleven patients, who received a transplant 6 (6-59) months previously, were included in the study. A first kinetic was done after administration of 60 mg of cinacalcet at 8 a.m. After a washout period of 1 week, the second kinetic was performed with cinacalcet given at 30 mg b.i.d within a 12-h period. RESULTS: During both kinetics, serum calcium (sCa), ionized calcium (sCa(2+)), albumin-corrected Ca and parathyroid hormone (PTH) levels decreased significantly. At 24 h after the second kinetic, sCa(2+) was significantly lower. After 1 year of cinacalcet treatment, given at the dose of 30 mg b.i.d., there was a significant decrease in sCa, sCa(2+), PTH levels and calcium x phosphorus (Ph) product. In contrast, Ph levels increased significantly. There was no significant change in renal function. CONCLUSION: Once- or twice-daily acute administration of cinacalcet to kidney-transplant patients has similar efficacy. One-year administration of cinacalcet, given as two daily doses, is safe and efficient. |
| Databáze: | OpenAIRE |
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