Diverse functions for different forms of nuclear actin
| Autor: | Jori Virtanen, Maria K. Vartiainen |
|---|---|
| Přispěvatelé: | Institute of Biotechnology, Nuclear organization by actin |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cytoplasm PROTEINS RNA-POLYMERASE-II Arp2/3 complex macromolecular substances Biology ACTIVATION 03 medical and health sciences FILAMENTS REVEALS Animals Humans Actin-binding protein Nuclear protein Cytoskeleton Actin Cell Nucleus COACTIVATOR COMPLEX STABILIZES Nuclear Proteins Actin remodeling Cell Biology Actins Chromatin Cell biology 030104 developmental biology DEPENDENT TRANSCRIPTION Profilin CELLS biology.protein 1182 Biochemistry cell and molecular biology MDia1 |
| Popis: | In addition to its essential roles as part of the cytoskeleton, actin has also been linked to many processes in the nucleus. Recent data has demonstrated the presence of both monomeric and polymeric actin in the nucleus, and implied distinct functional roles for these actin pools. Monomeric actin seems to be involved in regulation of gene expression through transcription factors, chromatin regulating complexes and RNA polymerases. In addition to cytoplasmic actin regulators, nuclear proteins, such as emerin, can regulate actin polymerization properties specifically in this compartment. Besides of structural roles, nuclear actin filaments may be required for organizing the nuclear contents and for the maintenance of genomic integrity. |
| Databáze: | OpenAIRE |
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