Intratumor heterogeneity in perfusion in human melanoma xenografts measured by contrast-enhanced magnetic resonance imaging
| Autor: | Ingvil Bjørnæs, Olav Kaalhus, Einar K. Rofstad, Gro A. Dahle, Heidi Lyng |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Fibrosarcoma Transplantation Heterologous Melanoma Experimental Biomedical Engineering Biophysics Hemodynamics Adenocarcinoma Mice Intratumor heterogeneity Cricetinae Tumor perfusion Tumor Cells Cultured medicine Animals Humans Radiology Nuclear Medicine and imaging Mice Inbred BALB C medicine.diagnostic_test business.industry Chemistry Microcirculation Melanoma Mammary Neoplasms Experimental Melanoma Amelanotic Magnetic resonance imaging Neoplasms Experimental Blood flow Models Theoretical Image Enhancement Prognosis medicine.disease Magnetic Resonance Imaging Rats Treatment Outcome Female Human melanoma Sarcoma Experimental Nuclear medicine business Perfusion Neoplasm Transplantation |
| Zdroj: | Magnetic Resonance Imaging. 18:997-1002 |
| ISSN: | 0730-725X |
| DOI: | 10.1016/s0730-725x(00)00188-0 |
| Popis: | The perfusion in tumors shows substantial spatial heterogeneity compared to that in normal tissues. The aim of the present study was to evaluate the intratumor heterogeneity in perfusion in tumors of two amelanotic human melanoma xenograft lines, A-07 and R-18, grown intradermally in Balb/c nu/nu mice. A non-invasive contrast-enhanced magnetic resonance imaging method yielding results in absolute values was applied. The perfusion was determined in manually defined regions of interest, corresponding to a whole tumor or to subregions of a tumor. The mean perfusion and the intertumor heterogeneity in perfusion were similar for the two tumor lines. For whole A-07 tumors, the perfusion ranged from 0.089 mL/(g · min) to 0.20 mL/(g · min) [mean: 0.15 mL/(g · min)], and for whole R-18 tumors, from 0.030 mL/(g · min) to 0.17 mL/(g · min) [mean: 0.13 mL/(g · min)]. The intratumor heterogeneity, on the other hand, was estimated to be 6.4 times larger in A-07 tumors than in R-18 tumors. The highest perfusion values, up to 0.69 mL/(g · min), were found in subregions of A-07 tumors. The intratumor heterogeneity was substantially larger than the intertumor heterogeneity in A-07 tumors, whereas in R-18 tumors, the intratumor heterogeneity was similar to the intertumor heterogeneity. These observations imply that measurements of mean tumor perfusion may have limited value as a predictive assay for outcome of treatment. |
| Databáze: | OpenAIRE |
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