Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos
| Autor: | Lijie Xu, Hua-Zhi Jin, Zhongshu Li, Obaid Ullah, Haixing Liu, Qing-Guo Jin, Ihsan Ali, Nan-Zhu Fang, Yan-Ya Fang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pterostilbene Apoptosis macromolecular substances CHOP Protective Agents Andrology 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Stilbenes medicine Animals Blastocyst Phosphorylation Endoplasmic Reticulum Chaperone BiP ATF6 Endoplasmic reticulum Tunicamycin Gene Expression Regulation Developmental Embryo Cell Biology General Medicine Endoplasmic Reticulum Stress Glutathione 030104 developmental biology medicine.anatomical_structure chemistry Proto-Oncogene Proteins c-bcl-2 030220 oncology & carcinogenesis Female Reactive Oxygen Species Developmental Biology Signal Transduction Transcription Factors |
| Zdroj: | In vitro cellulardevelopmental biology. Animal. 55(2) |
| ISSN: | 1543-706X |
| Popis: | Pterostilbene (PTS) mainly enriched in small fruits such as berries and grapes exerts an antioxidant effect. However, the protective effects of PTS against endoplasmic reticulum stress (ERS) have not yet been elucidated in mouse preimplantation embryo. ERS plays an important role in regulating the pathological and physiological processes, including embryonic development. We explored the protective effect of PTS on the tunicamycin (TM)-induced ERS in mouse preimplantation embryos. In vitro, culture medium was supplemented with different concentrations of TM and PTS. Our result indicated that treatment of zygotes with 0.5 μg/ml TM significantly decreased the development of day 4 blastocysts (P |
| Databáze: | OpenAIRE |
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