Long-Term Clinical and Angiographic Follow-up of Drug-Eluting Stents in Patients With ST-Elevation Acute Myocardial Infarction
| Autor: | Ana M. Planas-del Viejo, Mercedes Nadal-Barangé, Francisco Pomar-Domingo, Emilio Pérez-Fernández, Juan V. Vilar-Herrero, Victoria Jacas-Osborn |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment education Myocardial Infarction Coronary Angiography Restenosis Internal medicine medicine Humans Prospective Studies cardiovascular diseases Myocardial infarction Prospective cohort study business.industry ST elevation Percutaneous coronary intervention Stent Drug-Eluting Stents General Medicine Middle Aged medicine.disease Thrombosis Surgery Cross-Sectional Studies Drug-eluting stent Cardiology Female business Follow-Up Studies |
| Zdroj: | Revista Española de Cardiología (English Edition). 61:360-368 |
| ISSN: | 1885-5857 |
| DOI: | 10.1016/s1885-5857(08)60136-x |
| Popis: | Introduction and objectives Drug-eluting stents (DES) have proven to be effective in reducing the rate of restenosis and have, therefore, been incorporated into the treatment of patients with ST-elevation acute myocardial infarction (STEMI). The aim of this study was to investigate long-term clinical and angiographic outcomes following the use of DESs in patients with STEMI. Methods A prospective study involving clinical and angiographic follow-up was performed in 81 patients with STEMI who underwent percutaneous coronary intervention including DES implantation. This group was compared with 82 patients with similar characteristics who were treated with bare-metal stents (BMS) in an earlier period. Results At one year, there was no significant difference between the groups in the mortality (2.5% in the DES group vs 7.3% in the BMS group; P =.15) or reinfarction rate (4.8% in the DES group vs 4.8% in the BMS group; P =.98). The target lesion revascularization rate was significantly lower in the DES group (8.6% vs 23.2% in the BMS group; P =.001), as was the restenosis rate (13.8% vs 30.9% in the BMS group; P =.02). Acute or subacute stent thrombosis was diagnosed in 5 patients (3 with a DES and 2 with a BMS; P =.64), and one late stent thrombosis was detected after a year, in a sirolimuseluting stent. Conclusions Implantation of a DES in patients with STEMI did not result in a reduction in either the mortality or reinfarction rate at 1 year compared with BMS implantation. However, there were reductions in the rates of restenosis and target lesion revascularization. The incidence of thrombosis was similar with the 2 types of stent. |
| Databáze: | OpenAIRE |
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