Genetic diversity of the African malaria vector Anopheles gambiae
| Autor: | Matthew W. Hahn, Alison T. Isaacs, Samantha M. O’Loughlin, Tiago Antao, Austin Burt, Mara K. N. Lawniczak, Dominic P. Kwiatkowski, Christina M. Bergey, Michelle M. Riehle, Giordano Bottà, Boubacar Coulibaly, Martin J. Donnelly, Joao Dinis, Alessandra della Torre, Kirk A. Rockett, Krzysztof Kozak, Andrew D. Kern, Christina Hubbart, Nohal Elissa, Kate Rowlands, Bradley J. White, Eleanor Drury, Rachel Giacomantonio, Craig S. Wilding, Ian J. Wright, Kenneth D. Vernick, Michael C. Fontaine, Diego Ayala, Alistair Miles, Kyanne R. Rohatgi, Daniel Mead, Arlete D. Troco, Philip Bejon, Jim Stalker, Janet Midega, Nicholas J. Harding, Abdoulaye Diabaté, Nora J. Besansky, Henry D. Mawejje, Cinzia Malangone, Daniel R. Schrider, Paul Vauterin, H. Charles J. Godfray, Charles M. Mbogo, Igor V. Sharakhov, Anna E. Jeffreys, Seth Redmond, João Pinto, Dushyanth Jyothi, Chris S Clarkson, Victoria Cornelius, Krzysztof Kluczynski, Carlo Costantini, Lee Hart, Richard D. Pearson, Daniel E. Neafsey, Christa Henrichs, Bronwyn MacInnis, David Weetman, Beniamino Caputo, Ben Jeffery |
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| Přispěvatelé: | The Royal Society, Bill & Melinda Gates Foundation, Silicon Valley Community Foundation, Medical Research Council (MRC), Diversity, ecology, evolution & Adaptation of arthropod vectors (MIVEGEC-DEEVA), Evolution des Systèmes Vectoriels (ESV), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Groningen Institute for Evolutionary Life Sciences [Groningen] (GELIFES), University of Groningen [Groningen], Fontaine lab |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0106 biological sciences 0301 basic medicine Mosquito Control POSITIVE SELECTION Anopheles gambiae FLOW Genome Insect Web application development Guinea-Bissau 01 natural sciences Genome Partner working group Gene flow Insecticide Resistance Kenya Effective population size [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases RA0421 Gabon Sequencing and data production ComputingMilieux_MISCELLANEOUS Multidisciplinary biology Uganda [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] INTROGRESSION genomics malaria anopheles gambiae Anopheles Project coordination Crosses 3. Good health MOSQUITO Multidisciplinary Sciences Mosquito control QR180 Science & Technology - Other Topics Female Burkina Faso Sample collections—Angola Gene Flow X Chromosome General Science & Technology Data analysis group Mosquito Vectors Polymorphism Single Nucleotide 010603 evolutionary biology Article QH301 03 medical and health sciences CULICIDAE Cameroon parasitic diseases DIVERGENCE Animals Anopheles gambiae 1000 Genomes Consortium POPULATION-STRUCTURE INCIPIENT SPECIATION Population Density Genetic diversity Science & Technology Gene Drive Technology Genetic Variation Guinea biology.organism_classification Malaria 030104 developmental biology Evolutionary biology DROSOPHILA-MELANOGASTER Africa Threatened species [SDE.BE]Environmental Sciences/Biodiversity and Ecology RESISTANCE |
| Zdroj: | Nature Nature, Nature Publishing Group, 2017, 552 (7683), pp.96-100. ⟨10.1038/nature24995⟩ Nature, 552(7683), 96-100. Nature Publishing Group |
| ISSN: | 0028-0836 1476-4679 |
| DOI: | 10.1038/nature24995⟩ |
| Popis: | The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease(1). To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations. |
| Databáze: | OpenAIRE |
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