Genetic polymorphisms in estrogen receptors and sexual dimorphism in fat redistribution in HIV-infected patients on HAART
| Autor: | Jussara Maria Silveira, Eduardo Sprinz, Jorge Pinto Ribeiro, Regina Kuhmmer, Vanessa Suñé Mattevi, Aline S. Gasparotto, Rossana Patricia Basso, Cezar Arthur Tavares Pinheiro, Rosmeri Kuhmmer Lazzaretti, Mariângela Freitas da Silveira |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty HAART Genotype Lipodystrophy Immunology Estrogen receptor Adipose tissue Single-nucleotide polymorphism HIV Infections Estrogen receptor-b Estrogen receptor-a Real-Time Polymerase Chain Reaction Polymorphism Single Nucleotide Body Mass Index Medication Adherence Sex Factors Internal medicine Antiretroviral Therapy Highly Active medicine Prevalence Immunology and Allergy Body Fat Distribution Humans Lipoatrophy Dyslipidemias Metabolic Syndrome Analysis of Variance business.industry HIV-Associated Lipodystrophy Syndrome Estrogen Receptor alpha medicine.disease Sexual dimorphism Infectious Diseases Endocrinology Cross-Sectional Studies Dyslipidemia Female Metabolic syndrome business Brazil |
| Zdroj: | Repositório Institucional da FURG (RI FURG) Universidade Federal do Rio Grande (FURG) instacron:FURG |
| Popis: | Objective: To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-a (ERa) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERb (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. Design: Cross-sectional study. Methods: Blood samples and anthropometric measurements were collected from 614 patients at reference services in the cities of Porto Alegre, Pelotas and Rio Grande in Brazil. The SNPs were genotyped by real-time PCR. Results: The lipodystrophy subtype frequencies in patients of different sexes showed statistically significant differences; the atrophic pattern was more prevalent in men, and the hypertrophic pattern was more prevalent in women. Furthermore, metabolic syndrome prevalence was higher in women than in men. The ESR1 rs2813544 G-allele was associated with higher measurements of several anthropometric variables in women: BMI, total subcutaneous fat and subcutaneous fat of limbs. Additionally, patients who were AA homozygous for ESR2 rs3020450 presented an increased risk for developing lipoatrophy (prevalence ratio 1.37, 95% confidence interval 1.09–1.73, P ¼ 0.007). Conclusion: Significant differences in lipodystrophy and metabolic syndrome prevalence were detected between sexes. Moreover, the ESR1 gene (rs2813544) presented significant sex-specific associations with anthropometric variables, and the ESR2 gene (rs3020450) was associated with an increased risk of developing lipoatrophy. Our results suggest that these genes are in part responsible for the sexual dimorphism in fat tissue redistribution and patterns of lipodystrophy. |
| Databáze: | OpenAIRE |
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