Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial
| Autor: | Rafael Soares da Cunha, Francisco Carlos Groppo, Klinger de Souza Amorim, Allan Carlos Araújo de Oliveira, Anne Caroline Gercina, Liane Maciel de Almeida Souza, Liciane Dos Santos Menezes |
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| Rok vydání: | 2020 |
| Předmět: |
Molar
medicine.drug_class Placebo Anxiolytic 03 medical and health sciences 0302 clinical medicine Double-Blind Method medicine Humans Local anesthesia General Dentistry biology business.industry Passiflora Plant Extracts 030206 dentistry biology.organism_classification Passiflora incarnata Anti-Anxiety Agents 030220 oncology & carcinogenesis Anesthesia Tooth Extraction Erythrina mulungu Anxiety Midazolam Molar Third medicine.symptom business medicine.drug |
| Zdroj: | Clinical oral investigations. 25(3) |
| ISSN: | 1436-3771 |
| Popis: | This study aimed to compare the effects of Passiflora incarnata, Erythrina mulungu, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction. The volunteers underwent extraction of their third mandibular molars in a randomized, placebo-controlled, triple-blind, and parallel clinical trial. Passiflora incarnata (500 mg), Erythrina mulungu (500 mg), or midazolam (15 mg) was orally administered 60 min before the surgery. The anxiety level of participants was evaluated using questionnaires and measurements of physical parameters, including heart rate (HR), blood pressure (BP), and oxygen saturation (SpO2). A total of 200 volunteers were included in this clinical trial. Considering each procedure independently, no significant differences (p > 0.05) in BP, HR, and SpO2 were observed among the protocols. Passiflora incarnata showed a similar effect to midazolam but differed from placebo and mulungu, which were unable to control anxiety in this situation. Therefore, the results suggest that Passiflora configures an herbal medicine with an anxiolytic effect, adequate to use in third molar extractions. The use of Passiflora incarnata may be an alternative to benzodiazepines for controlling anxiety in patients scheduled for oral surgery under local anesthesia. ClinicalTrials.gov : ANSI-388.427 |
| Databáze: | OpenAIRE |
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