| Autor: |
Myriam Alexander, Steven E. Arnold, Stephanie J.B. Vos, Viviana Lisetti, Gunhild Waldemar, Marzena Zboch, David A. Wolk, Sebastiaan Engelborghs, Sabine Hellwig, Adrian Ivanoiu, José Luis Molinuevo, Duk L. Na, Sebastian Köhler, Elisabeth Kapaki, Catarina R. Oliveira, Enrica Cavedo, Ina S. Almdahl, Karine Madsen, Mark A. Mintun, Frans R.J. Verhey, Juha O. Rinne, John C. Morris, Hanne Struyfs, George P. Paraskevas, Oliver Peters, Ann D. Cohen, Philip Scheltens, Willemijn J. Jansen, Linda J C van Waalwijk van Doorn, Eckart Rüther, Sanna-Kaisa Herukka, Osama Sabri, Mark Forrest Gordon, Yvonne Freund-Levi, Rik Vandenberghe, Lucrezia Hausner, Marie Sarazin, Kristian Steen Frederiksen, Inês Baldeiras, William E. Klunk, Susan M. Landau, Timo Grimmer, Lutz Froelich, Betty M. Tijms, Dong Young Lee, Peter Johannsen, Aleksandra Klimkowicz-Mrowiec, Charlotte E. Teunissen, Kaj Blennow, Mony J. de Leon, Christopher C. Rowe, Alberto Lleó, Uroš Rot, Pascual Sánchez-Juan, Daniel Alcolea, Henryk Barthel, Wiesje M. van der Flier, Olga Meulenbroek, Tomasz Gabryelewicz, Tormod Fladby, Andrew B. Newberg, Åsa K. Wallin, Marcel M. Verbeek, Lucilla Parnetti, Bart N.M. van Berckel, Vincent Mok, Oskar Hansson, Victor L. Villemagne, David J. Brooks, Helmut Hildebrandt, Koen Van Laere, Dag Aarsland, Inez H.G.B. Ramakers, Harald Hampel, Elena Chipi, Henrik Zetterberg, Erik Stomrud, Hilkka Soininen, Juan Fortea, Gil D. Rabinovici, Anders Wallin, Vincent Camus, Gayan Perera, Julius Popp, Pieter Jelle Visser, Magda Tsolaki, Johannes Kornhuber, Anne M. Fagan, Niklas Mattsson, William J. Jagust, Luiza Spiru, Hanne M. Møllergård, Adam S. Fleisher, Isabel Santana, Jens Wiltfang, Jan Marcusson, Alexander Drzezga, Giovanni B. Frisoni, Catherine M. Roe, Mark A. van Buchem, Norman Koglin, Johannes Schröder, Pauline Aalten, Olymbia Gkatzima, Lorena Rami, Wolfgang Maier, Agneta Nordberg, Alexandre de Mendonça, Gerald Novak, Gaël Chételat, Arto Nordlund, Milica G. Kramberger, Rik Ossenkoppele, Barbara Mroczko, Kewei Chen, Eloy Rodríguez-Rodríguez, Stefan Förster, Sang W. Seo, Philipp T. Meyer |
| Přispěvatelé: |
Clinical sciences, Neurology, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), Amyloid Biomarker Study Group, Frisoni, Giovanni, Popp, Julius, Amsterdam Neuroscience - Neurodegeneration, APH - Personalized Medicine, APH - Methodology, Radiology and nuclear medicine, Laboratory Medicine, CCA - Imaging and biomarkers |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
JAMA psychiatry 75(1), 84 (2018). doi:10.1001/jamapsychiatry.2017.3391
JAMA Psychiatry, 75, 1, pp. 84-95
JAMA Psychiatry, 75, 84-95
JAMA Psychiatry
JAMA Psychiatry, 75(1), 84-95. American Medical Association
Amyloid Biomarker Study Group 2018, ' Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia ', JAMA Psychiatry, vol. 75, no. 1, pp. 84-95 . https://doi.org/10.1001/jamapsychiatry.2017.3391
JAMA psychiatry
JAMA Psychiatry, Vol. 75, No 1 (2018) pp. 84-95 |
| ISSN: |
2168-622X |
| DOI: |
10.1001/jamapsychiatry.2017.3391 |
| Popis: |
Contains fulltext : 190311.pdf (Publisher’s version ) (Closed access) Importance: Cerebral amyloid-beta aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials. Objective: To investigate whether amyloid-beta aggregation is associated with cognitive functioning in persons without dementia. Design, Setting, and Participants: This cross-sectional study included 2908 participants with normal cognition and 4133 with mild cognitive impairment (MCI) from 53 studies in the multicenter Amyloid Biomarker Study. Normal cognition was defined as having no cognitive concerns for which medical help was sought and scores within the normal range on cognitive tests. Mild cognitive impairment was diagnosed according to published criteria. Study inclusion began in 2013 and is ongoing. Data analysis was performed in January 2017. Main Outcomes and Measures: Global cognitive performance as assessed by the Mini-Mental State Examination (MMSE) and episodic memory performance as assessed by a verbal word learning test. Amyloid aggregation was measured with positron emission tomography or cerebrospinal fluid biomarkers and dichotomized as negative (normal) or positive (abnormal) according to study-specific cutoffs. Generalized estimating equations were used to examine the association between amyloid aggregation and low cognitive scores (MMSE score |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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