Abscopal Effect after Radiosurgery for Solitary Brain Metastasis from Non-small Cell Lung Cancer
| Autor: | Paul Chuba, Jerome Seid, Kyle Verdecchia, Andrew J Hamilton |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
squamous cell carcinoma
0301 basic medicine Oncology medicine.medical_specialty abscopal effect medicine.medical_treatment Spontaneous remission radiation therapy Radiosurgery 03 medical and health sciences 0302 clinical medicine brain metastases Internal medicine medicine Lung cancer radiotherapy non-small cell lung cancer irradiation business.industry radiosurgery General Engineering Cancer Abscopal effect Immunotherapy medicine.disease Radiation therapy 030104 developmental biology 030220 oncology & carcinogenesis Radiation Oncology immunotherapy Radiology business Brain metastasis |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.3777 |
| Popis: | The abscopal effect is a phenomenon relating to the treatment of metastatic cancer in which localized irradiation to a tumor concurrently causes shrinkage of tumors distant from the area of treatment. Localized radiotherapy is thought to cause anti-tumor immunologic responses that lead to regression and remission of cancers distant to the initial location of treatment. We present a 47-year-old male with brain metastasis from non-small cell lung cancer (NSCLC) who went into remission following stereotactic radiosurgery treatment to a brain lesion, in the absence of systemic treatment. We discuss the novelty of this case and its importance to future research on the abscopal effect. Though it is difficult to distinguish the abscopal effect from spontaneous remission of non-targeted cancer, this report sheds insight on the potential for improving treatment for the leading cause of cancer death worldwide. |
| Databáze: | OpenAIRE |
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