Ablation of Ghrelin O-Acyltransferase Does Not Improve Glucose Intolerance or Body Adiposity in Mice on a Leptin-Deficient ob/ob Background
Autor: | Henriette Kirchner, Matthias H. Tschöp, Jenna Holland, Dhiraj G. Kabra, Paul T. Pfluger, Kristy M. Heppner |
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Jazyk: | angličtina |
Rok vydání: | 2013 |
Předmět: |
Leptin
Male Anatomy and Physiology Mouse Acylation medicine.medical_treatment Mice Obese lcsh:Medicine Gene Knockout Techniques Mice Endocrinology 0302 clinical medicine Homeostasis Glucose homeostasis lcsh:Science Adiposity Mice Knockout 0303 health sciences Multidisciplinary Leptin Deficiency digestive oral and skin physiology Animal Models Ghrelin Ghrelin O-acyltransferase 3. Good health Phenotype Medicine Female hormones hormone substitutes and hormone antagonists Research Article medicine.medical_specialty Endocrine System 030209 endocrinology & metabolism Carbohydrate metabolism Biology 03 medical and health sciences Model Organisms Internal medicine Glucose Intolerance medicine Animals Obesity 030304 developmental biology Diabetic Endocrinology Endocrine Physiology Insulin Body Weight lcsh:R Membrane Proteins Diabetes Mellitus Type 2 Hormones Glucose lcsh:Q Physiological Processes Protein Processing Post-Translational Acyltransferases |
Zdroj: | PLoS ONE; Vol 8 PLoS ONE 8:e61822 (2013) PLoS ONE PLoS ONE, Vol 8, Iss 4, p e61822 (2013) |
ISSN: | 1932-6203 |
DOI: | 10.1371/journal.pone.0061822 |
Popis: | Type 2 Diabetes is a global health burden and based on current estimates will become an even larger problem in the future. Developing new strategies to prevent and treat diabetes is a scientific challenge of high priority. The stomach hormone ghrelin has been associated with playing a role in the regulation of glucose homeostasis. However, its precise mechanism and impact on whole glucose metabolism remains to be elucidated. This study aims to clarify the role of the two ghrelin isoforms acyl- and desacyl ghrelin in regulating glucose homeostasis. Therefore ghrelin activating enzyme Ghrelin-O-acyltransferase (GOAT) was ablated in leptin-deficient ob/ob mice to study whether specific acyl ghrelin deficiency or desacyl ghrelin abundance modifies glucose tolerance on a massively obese background. As targeted deletion of acyl ghrelin does not improve glucose homeostasis in our GOAT-ob/ob mouse model we conclude that neither acyl ghrelin nor the increased ratio of desacyl/acyl ghrelin is crucial for controlling glucose homeostasis in the here presented model of massive obesity induced by leptin deficiency. |
Databáze: | OpenAIRE |
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