Haemodiafiltration elicits less platelet activation compared to haemodialysis
| Autor: | József Balla, Renáta Hudák, Harjit Pal Bhattoa, Zsolt Fejes, Gergely Becs, János Kappelmayer, Ildikó Beke Debreceni |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Nephrology
Male P-selectin medicine.medical_treatment 030232 urology & nephrology Monocyte-platelet aggregate 030204 cardiovascular system & hematology Gastroenterology Monocytes 0302 clinical medicine Platelet biology medicine.diagnostic_test Orvostudományok Middle Aged Haemodialysis P-Selectin Haemodiafiltration Female E-Selectin Research Article Adult medicine.medical_specialty Adolescent Hemodiafiltration Klinikai orvostudományok Flow cytometry 03 medical and health sciences Young Adult Von Willebrand factor Antigen Renal Dialysis Internal medicine von Willebrand Factor medicine Humans Platelet activation ESRD Dialysis Aged business.industry Heparin Anticoagulants Endothelial Cells Platelet Activation Immunology biology.protein Kidney Failure Chronic business Biomarkers |
| Zdroj: | BMC Nephrology |
| Popis: | Background Mortality in patients with end-stage renal disorders is often a consequence of cardiovascular complications. Renal replacement therapies may contribute to this morbidity by promoting cellular activation. In renal failure patients peripheral blood samples were investigated for platelet and endothelial cell activation markers to compare the effects of haemodiafiltration (HDF) and haemodialysis (HD). Methods Overall 28 patients were included in the study. Platelet P-selectin and leukocyte - platelet heterotypic aggregates were studied by flow cytometry. Soluble P- and E-selectin values were determined by ELISA, while von Willebrand factor (vWF) antigen levels were measured by immunoturbidimetry. Statistical analysis was done by the SPSS v22 software. Results Platelet surface P-selectin was below 3.0 % in healthy controls, but it was higher during the dialysis after 4 h, 8 % and 14.3 % in HDF and HD, respectively. Monocyte-platelet heterotypic aggregates were significantly elevated after 4 h in both treatments, up to 69.2 % in HDF and to 82.9 % in HD. Soluble P-selectin levels were also significantly elevated by the end of both treatment procedures (p |
| Databáze: | OpenAIRE |
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