Burden of varicella in the Asia-Pacific region: a systematic literature review
Autor: | Barbara J. Kuter, Helen Marshall, Lara J. Wolfson, Eun Hwa Choi, Ping Ing Lee, Jin Oh Kim, Jaydeep Choudhury, Kulkanya Chokephaibulkit, Anne Eng Neo Goh |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Asia Immunology Disease Asia pacific region Pacific Islands 03 medical and health sciences 0302 clinical medicine Chickenpox Cost of Illness Seroepidemiologic Studies Environmental health Drug Discovery Epidemiology medicine Humans 030212 general & internal medicine Disease burden Pharmacology business.industry Incidence food and beverages Survival Analysis 030104 developmental biology Systematic review Molecular Medicine business |
Zdroj: | Expert review of vaccines. 18(5) |
ISSN: | 1744-8395 |
Popis: | Introduction: Varicella is a highly contagious infection that can lead to serious complications, particularly in high-risk groups; however, it is vaccine preventable. Disease awareness and understanding of the disease burden can strongly influence vaccine coverage. This review provides insight into the current epidemiology and the importance of varicella from both public health and economic perspectives across the Asia-Pacific (APAC) region. Areas covered: A systematic literature review was conducted to identify studies on the incidence, seroprevalence, fatality rate and complication rate of varicella. Economic burden studies were also captured. Altogether, 125 studies were identified across the region; these were supplemented by government reports (gray data). Reported vaccine coverage varied from 2.8% to 97%; a key influencing factor was inclusion of the varicella vaccine in national immunization programs. In general, varicella incidence in the unvaccinated population was highest in children ≤5 years old and seroprevalence increased with age. Economic analyses highlighted the cost-saving potential of vaccination programs, especially from a societal perspective. Expert opinion: Varicella-related data varied greatly across the APAC region, highlighting the need to better understand the burden of varicella in this area, and particularly identified the need for better surveillance and reporting. |
Databáze: | OpenAIRE |
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