White matter networks dissociate semantic control from semantic knowledge representations: Evidence from voxel-based lesion-symptom mapping
| Autor: | Mingyue Luo, Luping Song, Zaizhu Han, Xiaoxia Du, Yan Chen, Keliang Chen, Junhua Ding, Qing Yang, Nan Zhang, Yumei Zhang, Yingru Lv, Qihao Guo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Cognitive Neuroscience Semantic dementia Experimental and Cognitive Psychology Neuropsychological Tests computer.software_genre 050105 experimental psychology White matter Lesion 03 medical and health sciences 0302 clinical medicine Arts and Humanities (miscellaneous) Voxel Aphasia Developmental and Educational Psychology medicine Humans Semantic memory 0501 psychology and cognitive sciences Aged Brain Mapping 05 social sciences Semantic control Middle Aged medicine.disease White Matter Semantics Neuropsychology and Physiological Psychology medicine.anatomical_structure Female medicine.symptom Psychology computer 030217 neurology & neurosurgery Neuroanatomy Cognitive psychology |
| Zdroj: | Cognitive Neuropsychology. 37:450-465 |
| ISSN: | 1464-0627 0264-3294 |
| DOI: | 10.1080/02643294.2020.1767560 |
| Popis: | Although semantic system is composed of two distinctive processes (i.e., semantic knowledge and semantic control), it remains unknown in which way these two processes dissociate from each other. Investigating the white matter neuroanatomy underlying these processes helps improve understanding of this question. To address this issue, we recruited brain-damaged patients with semantic dementia (SD) and semantic aphasia (SA), who had selective predominant deficits in semantic knowledge and semantic control, respectively. We built regression models to identify the white matter network associated with the semantic performance of each patient group. Semantic knowledge deficits in the SD patients were associated with damage to the left medial temporal network, while semantic control deficits in the SA patients were associated with damage to the other two networks (left frontal-temporal/occipital and frontal-subcortical networks). The further voxel-based analysis revealed additional semantic-relevant white matter tracts. These findings specify different processing principles of the components in semantic system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |