Systematic review of studies on drug-delivery systems for management of temporomandibular-joint osteoarthritis
| Autor: | Nicolas Blanchemain, Florent Barry, Romain Nicot, Feng Chai, Henry Chijcheapaza-Flores, Maria José Garcia-Fernandez |
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| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Anti-Inflammatory Agents Poloxamer Osteoarthritis chemistry.chemical_compound Drug Delivery Systems Polylactic Acid-Polyglycolic Acid Copolymer medicine Animals Humans Hyaluronic Acid Intensive care medicine Short duration Micelles Chitosan Nonsteroidal business.industry Drug administration Hydrogels Temporomandibular Joint Disorders medicine.disease Lipids Test duration Rats Otorhinolaryngology chemistry Drug delivery Surgery Delivery system Oral Surgery business |
| Zdroj: | Journal of Stomatology, Oral and Maxillofacial Surgery. 123:e336-e341 |
| ISSN: | 2468-7855 |
| Popis: | Introduction Temporomandibular-joint osteoarthritis (TMJOA) management is a major challenge. Minimally invasive therapies (based mainly on injections) have been developed to increase local efficacy and limit adverse systemic effects. However, the requirement for repeat injections due to a short duration of action and expensive healthcare costs have pushed researchers to develop, via tissue engineering, drug-delivery systems (DDSs). In this literature systematic review, we aim to provide an overview of studies that tested DDSs on a TMJOA model. Material and methods We searched on PubMed for articles published from November 1965 to March 2021 on DDSs using a TMJOA model. We highlighted the different DDSs and the active molecule employed. Route of drug administration, model type, test duration, and efficacy duration were assessed. To evaluate the quality of each study, a protocol bias was tested using QUADAS-2™. Results Of the 10 studies that were full text-screened, four used a poly(lactic-co-glycolic acid)-based delivery system. The other DDSs employed chitosan-based hydrogels, microneedles patches, nanostructured lipid carriers, or poloxamer micelles. Hyaluronic acid, nonsteroidal anti-inflammatory drugs, and analgesics were used as active molecules in five studies. The main way to administer DDSs was intra-articular injection and the most used model was the rat. Discussion Various DDSs and active molecules have been studied on a TMJOA model that could aid TMJOA management. Further works using longer test durations are necessary to validate these advances. |
| Databáze: | OpenAIRE |
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