Biomarkers of diagnosis and resolution of food allergy
Autor: | Alexandra F. Santos, Ru-Xin Foong |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Allergy Immunology 03 medical and health sciences 0302 clinical medicine Food allergy Clinical history medicine Animals Humans Nuts Immunology and Allergy 030212 general & internal medicine Intensive care medicine Oral tolerance Predictive testing Skin Tests Modalities business.industry Oral food challenge digestive oral and skin physiology Allergens Immunoglobulin E medicine.disease Editorial 030228 respiratory system Pediatrics Perinatology and Child Health Quality of Life Cattle Female Milk Hypersensitivity business Developed country Biomarkers Food Hypersensitivity |
Zdroj: | Pediatric Allergy and Immunology |
ISSN: | 1399-3038 0905-6157 |
Popis: | Food allergy is increasing in prevalence, affecting up to 10% of children in developed countries. Food allergy can significantly affect the quality of life and well-being of patients and their families; therefore, an accurate diagnosis is of extreme importance. Some food allergies can spontaneously resolve in 50%-60% of cow's milk and egg-allergic, 20% of peanut-allergic and 9% of tree nut-allergic children by school age. For that reason, food-allergic status should be monitored over time to determine when to reintroduce the food back into the child's diet. The gold-standard to confirm the diagnosis and the resolution of food allergy is an oral food challenge; however, this involves the risk of causing an acute-allergic reaction and requires clinical experience and resources to treat allergic reactions of any degree of severity. In the clinical setting, biomarkers have been used and validated to enable an accurate diagnosis when combined with the clinical history, deferring the oral food challenge, whenever possible. In this review, we cover the tools available to support the diagnosis of food allergies and to predict food allergy resolution over time. We review the latest evidence on different testing modalities and how effective they are in guiding clinical decision making in practice. We also evaluate predictive test cut-offs for the more common food allergens to try and provide guidance on when challenges might be most successful in determining oral tolerance in children. |
Databáze: | OpenAIRE |
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