The prevalence of bone aluminum deposition in renal osteodystrophy and its relation to the response to calcitriol therapy
| Autor: | Donald J. Sherrard, Norma A. Maloney, Allen C. Alfrey, Jack W. Coburn, Susan M. Ott |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Chronic Kidney Disease-Mineral and Bone Disorder
Pathology medicine.medical_specialty Calcitriol business.industry Histocytochemistry Urology General Medicine medicine.disease Stain Bone and Bones Staining Aluminum deposition Osteomalacia medicine Humans In patient Renal osteodystrophy Square Millimeter business medicine.drug Aluminum |
| Zdroj: | The New England journal of medicine. 307(12) |
| ISSN: | 0028-4793 |
| Popis: | A histochemical stain for bone aluminum allowed us to determine the prevalence and staining characteristics of aluminum in renal osteodystrophy. The staining method correlated well with the results of atomic-absorption studies in 96 samples (r = 0.81; P less than 0.001). We examined 315 bone-biopsy samples. No aluminum was seen in controls or patients with nonrenal bone disease. In renal osteodystrophy, the mean level of stainable aluminum was significantly higher in osteomalacic lesions (1.12 +/- 0.09 mm per square millimeter of tissue area) than in mild, mixed, of fibrotic lesions (0.43 +/- 0.06, 0.34 +/- 0.11, and 0.10 +/- 0.03 mm per square millimeter, respectively; P less than 0.001). Seventy per cent of osteomalacic samples had heavy aluminum staining. The bone-apposition rate, measured by double tetracycline labels, was low in 89 per cent of the samples with high levels of aluminum. The mean level of stainable bone aluminum in patients who had a clinical response to calcitriol was significantly lower than in those who did not respond (0.13 +/- 0.4 vs. 1.06 +/- 0.9 mm per square millimeter; P less than 0.01). We conclude that aluminum deposition is associated with impaired bone formation or mineralization and with a poor response to calcitriol therapy. |
| Databáze: | OpenAIRE |
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