Microtubule Organization in Striated Muscle Cells
| Autor: | Marina Leone, Robert Becker, Felix B. Engel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cellular differentiation cardiomyocytes Review Biology Microtubules 03 medical and health sciences 0302 clinical medicine Medizinische Fakultät Microtubule medicine Myocyte Animals Humans ddc:610 skeletal muscle lcsh:QH301-705.5 Centrosome Muscle Cells Myogenesis Cell Cycle Skeletal muscle Microtubule organizing center General Medicine Cell cycle Muscle Striated Cell biology 030104 developmental biology medicine.anatomical_structure MTOC lcsh:Biology (General) non-centrosomal MTOC 030217 neurology & neurosurgery Microtubule-Organizing Center |
| Zdroj: | Cells Cells, Vol 9, Iss 1395, p 1395 (2020) |
| ISSN: | 2073-4409 |
| Popis: | Distinctly organized microtubule networks contribute to the function of differentiated cell types such as neurons, epithelial cells, skeletal myotubes, and cardiomyocytes. In striated (i.e., skeletal and cardiac) muscle cells, the nuclear envelope acts as the dominant microtubule-organizing center (MTOC) and the function of the centrosome—the canonical MTOC of mammalian cells—is attenuated, a common feature of differentiated cell types. We summarize the mechanisms known to underlie MTOC formation at the nuclear envelope, discuss the significance of the nuclear envelope MTOC for muscle function and cell cycle progression, and outline potential mechanisms of centrosome attenuation. |
| Databáze: | OpenAIRE |
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