Effect of mesoporous silica and its combination with hydroxyapatite on the regeneration of rabbit's bone defects: A pilot study
| Autor: | Yolanda Piñeiro Redondo, Abel García García, Francisco José Gómez García, Susana Yáñez Vilar, José Rivas, Mario Pérez Sayáns, Cintia Micaela Chamorro Petronacci, Berta Rivas Mundiña, Pía López Jornet, José Crecente Campo |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Bone Regeneration
medicine.medical_treatment Biomedical Engineering Biocompatible Materials Pilot Projects 02 engineering and technology Dehiscence Biomaterials 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Tibia Dental implant business.industry Regeneration (biology) Rabbit (nuclear engineering) 030206 dentistry General Medicine Periodontology Mesoporous silica 021001 nanoscience & nanotechnology Silicon Dioxide Durapatite Rabbits 0210 nano-technology business Bone volume Biomedical engineering |
| Zdroj: | Bio-medical materials and engineering. 32(5) |
| ISSN: | 1878-3619 |
| Popis: | BACKGROUND: Bone volume augmentation is a routine technique used in oral implantology and periodontology. Advances in the surgical techniques and the biomaterials field have allowed a greater accessibility to these treatments. Nevertheless, dehiscence and fenestrations incidence during dental implant procedures are still common in patients with bone loss. OBJECTIVE: The main objective is to evaluate in a pilot experimental study the biological response to mesoporous silica (MS) hybrid scaffolds and its regenerative capacity in different formulations. METHODS: Two defects per rabbit tibia were performed (one for control and other for test) and the biomaterials tested in this study have been used to fill the bone defects, prepared in two different formulations (3D hybrid scaffolds or powdered material, in 100% pure MS form, or 50% MS with 50% hydroxyapatite (HA). Euthanasia was performed 4 months after surgery for bone histopathological study and radiographic images were acquired by computerized microtomography. RESULTS: Results showed that radiographically and histopathologically pure MS formulations lead to a lower biological response, e.g when formulated with HA, the osteogenic response in terms of osteoconduction was greater. CONCLUSIONS: We observed tolerance and lack of toxicity of the MS and HA, without registering any type of local or systemic allergic reaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|