6-Thioguanine for Crohn's disease during pregnancy: thiopurine metabolite measurements in both mother and child
| Autor: | Chris J. J. Mulder, Adriana J. Remmink, Abraham J. Wilhelm, John M.G. van Vugt, Adriaan A. van Bodegraven, Nanne K. H. de Boer, Ruurd M. van Elburg |
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| Přispěvatelé: | Other departments, VU University medical center |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy High-Risk Gestational Age Azathioprine Risk Assessment Severity of Illness Index Inflammatory bowel disease Gastroenterology Drug Administration Schedule Tioguanine Crohn Disease Pregnancy Internal medicine Humans Medicine Thioguanine Maternal-Fetal Exchange Crohn's disease Dose-Response Relationship Drug Thiopurine methyltransferase biology business.industry Pregnancy Outcome Gestational age medicine.disease Pregnancy Complications Immunology biology.protein Female Methotrexate business Follow-Up Studies medicine.drug |
| Zdroj: | De Boer, NK, van Elburg, R M, Wilhelm, A J, Remmink, A J, van Vugt, J M G, Mulder, C J J & van Bodegraven, A A 2005, ' 6-Thioguanine for Crohn's disease during pregnancy: thiopurine metabolite measurements in both mother and child ', Scandinavian Journal of Gastroenterology, vol. 40, no. 11, pp. 1374-1377 . https://doi.org/10.1080/00365520510024089 Scandinavian journal of gastroenterology, 40(11), 1374-1377. Informa Healthcare Scandinavian Journal of Gastroenterology, 40(11), 1374-1377. Informa Healthcare |
| ISSN: | 0036-5521 |
| DOI: | 10.1080/00365520510024089 |
| Popis: | 6-Thioguanine is used as an escape thiopurine for treating inflammatory bowel disease patients intolerant or refractory to azathioprine, 6-mercaptopurine or methotrexate. Case reports show conflicting data on the use of 6-thioguanine throughout pregnancy. The administration of the standard thiopurines is believed to be relatively safe. We describe two patients with Crohn's disease treated with low-dose 6-thioguanine during all trimesters of their pregnancies. The pregnancies resulted in two healthy infants: without congenital abnormalities, laboratory signs of myelosuppression or hepatocellular injury. Thiopurine metabolites were measured in mother and infant. Significantly lower levels of 6-thioguaninenucleotides were found in the erythrocytes of the infant compared to the mother ( ratio 1: 12). Further studies are needed to determine the clinical importance of thiopurine metabolite measurements during pregnancy in mother and child |
| Databáze: | OpenAIRE |
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