Vaccination Hesitancy among Health-Care-Workers in Academic Hospitals Is Associated with a 12-Fold Increase in the Risk of COVID-19 Infection: A Nine-Month Greek Cohort Study
| Autor: | Fotinie Ntziora, Evangelia Georgia Kostaki, Ioannis Grigoropoulos, Amalia Karapanou, Ismini Kliani, Maria Mylona, Alexa Thomollari, Sotirios Tsiodras, Theoklis Zaoutis, Dimitrios Paraskevis, Nikolaos V. Sipsas, Anastasia Antoniadou, Petros P. Sfikakis |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Risk Coronavirus disease 2019 (COVID-19) vaccine infection rate hesitancy Health-Care-Workers (HCWs) Health Personnel education Severity of Illness Index Microbiology Article Tertiary Care Centers Virology Humans BNT162 Vaccine Retrospective Studies Greece SARS-CoV-2 Vaccination COVID-19 virus diseases Middle Aged QR1-502 Infectious Diseases Female Vaccination Hesitancy |
| Zdroj: | Viruses, Vol 14, Iss 26, p 26 (2022) Viruses; Volume 14; Issue 1; Pages: 26 Viruses |
| ISSN: | 1999-4915 |
| Popis: | Health-Care-Workers (HCWs) are considered at high risk for SARS-CoV-2 infection. We sought to compare rates and severity of Coronavirus disease 2019 (COVID-19) among vaccinated and unvaccinated HCWs conducting a retrospective cohort study in two tertiary Academic Hospitals, namely Laiko and Attikon, in Athens, Greece. Vaccinated by BNT162b2 Pfizer-BioNTech COVID-19 mRNA vaccine and unvaccinated HCWs were included and data were collected between 1 January 2021 and 15 September 2021. Overall, 2921 of 3219 HCWs without a history of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection were fully vaccinated during the study period (90.7% at each Hospital). Demographic characteristics were comparable between 102/2921 (3.5%) vaccinated and 88/298 (29.5%) unvaccinated HCWs with COVID-19, although age and occupation differed significantly. None were in need of hospital admission in the vaccinated Group, whereas in the unvaccinated Group 4/88 (4.5%) were hospitalized and one (1.1%) died. Multivariable logistic regression analysis revealed that lack of vaccination was an independent risk factor for COVID-19 with an odds ratio 11.54 (95% CI: 10.75–12.40). Vaccination hesitancy among HCWs resulted to highly increased COVID-19 rates; almost one in three unvaccinated HCWs was SARS-CoV-2 infected during the 9-month period. The absolute need of vaccination of HCWs, including boosting dose, is highlighted. Evidence should be used appropriately to overcome any hesitancy. |
| Databáze: | OpenAIRE |
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