CXCL9: evidence and contradictions for its role in tumor progression

Autor: Jingmei Liu, Xin Li, Shuping Ding, Ping Han, Qiang Ding, Yuhui Fan, Dean Tian, Panpan Lu, Yujia Xia, Mei Liu
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Cancer Research
Chemokine
Receptors
CXCR3
Angiogenesis
tumor suppressor
T-Lymphocytes
Biology
CXCR3
lcsh:RC254-282
Chemokine CXCL9
Models
Biological
Metastasis
03 medical and health sciences
0302 clinical medicine
stomatognathic system
immune system diseases
Neoplasms
medicine
Animals
Humans
Radiology
Nuclear Medicine and imaging
skin and connective tissue diseases
Promoter Regions
Genetic
Original Research
Cancer Biology
Cancer
Oncogene Proteins
therapy
Tumor Suppressor Proteins
tumor promoter
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Monokine
stomatognathic diseases
030104 developmental biology
Cell Transformation
Neoplastic
Oncology
Tumor progression
030220 oncology & carcinogenesis
CXCL9
Immunology
biology.protein
Disease Progression
Biomarkers
Zdroj: Cancer Medicine
Cancer Medicine, Vol 5, Iss 11, Pp 3246-3259 (2016)
ISSN: 2045-7634
Popis: Chemokines are a group of low molecular weight peptides. Their major function is the recruitment of leukocytes to inflammation sites, but they also play a key role in tumor growth, angiogenesis, and metastasis. In the last few years, accumulated experimental evidence supports that monokine induced by interferon (IFN)‐gamma (CXCL9), a member of CXC chemokine family and known to attract CXCR3‐ (CXCR3‐A and CXCR3‐B) T lymphocytes, is involved in the pathogenesis of a variety of physiologic diseases during their initiation and their maintenance. This review for the first time presents the most comprehensive summary for the role of CXCL9 in different types of tumors, and demonstrates its contradictory role of CXCL9 in tumor progression. Altogether, this is a useful resource for researchers investigating therapeutic opportunities for cancer.
Databáze: OpenAIRE
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