Pulmonary benign metastasizing leiomyoma: A case report
| Autor: | Terrance Barnes, Annum Faisal, Glenn M. VanOtteren, Malik M H S Khan, Hussain Ibrahim |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Case Report Lung biopsy Chest pain 03 medical and health sciences 0302 clinical medicine Medicine 030212 general & internal medicine lcsh:RC705-779 Uterine leiomyoma Lung business.industry lcsh:Diseases of the respiratory system medicine.disease Pulmonary metastasis Aromatase inhibitors medicine.anatomical_structure Leiomyoma 030220 oncology & carcinogenesis Smooth Muscle Tumor Benign metastasizing leiomyoma medicine.symptom business Wedge resection (lung) Rare disease |
| Zdroj: | Respiratory Medicine Case Reports Respiratory Medicine Case Reports, Vol 24, Iss, Pp 117-121 (2018) |
| ISSN: | 2213-0071 |
| DOI: | 10.1016/j.rmcr.2018.04.017 |
| Popis: | Uterine leiomyoma is the most common benign gynecological tumor. Rarely, it has benign extra-uterine growth patterns, including benign metastasizing leiomyoma (BML), with lungs being the most common metastatic site.We present a case of a 47-year-old female who, 3 years prior to presentation, underwent abdominal supra-cervical hysterectomy for benign leiomyoma. Approximately 6 months prior to presentation, she was seen for shortness of breath and chest pain. A CT of the chest revealed multiple new non-calcified pulmonary nodules bilaterally. PET/CT demonstrated mild FDG uptake in multiple lung nodules, with no significant extra-thoracic sites of abnormal FDG uptake. A CT guided lung biopsy showed a low grade, smooth muscle tumor. Immunohistochemical staining was positive for smooth-muscle actin and desmin, estrogen and progesterone receptor and was negative for CD117, HMB-45, CD34, pan cytokeratin and EMA. She underwent wedge resection of one of the nodules which confirmed the above findings. A cytogenetic analysis was also performed, which was consistent with pulmonary BML. She ultimately underwent left lower lobe resection and was started on a daily aromatase inhibitor.BML is a rare disease usually seen in women of reproductive age. The pathogenesis and treatment remain controversial. BML mostly tends to have an indolent course and a favorable outcome. Keywords: Benign metastasizing leiomyoma, Pulmonary metastasis, Aromatase inhibitors |
| Databáze: | OpenAIRE |
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