Association of the risk of development of hypothyroidism after iodine 131 treatment with the pretreatment pattern of sodium pertechnetate Tc 99m uptake in the thyroid gland in cats with hyperthyroidism: 165 cases (1990-2002)
| Autor: | Nathen L Dykes, Janet M. Scarlett, Mitzi K. Zarfoss, Stephanie G. Nykamp |
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| Rok vydání: | 2005 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Thyroid Hormones endocrine system diseases Thyroid Gland chemistry.chemical_element Iodine Cat Diseases Hyperthyroidism Iodine Radioisotopes Hypothyroidism Risk Factors Internal medicine medicine Animals Radionuclide imaging Radionuclide Imaging Retrospective Studies Sodium Pertechnetate Tc 99m CATS General Veterinary business.industry Thyroid Endocrinology medicine.anatomical_structure chemistry Thyroid hormones Cats Female business After treatment |
| Zdroj: | Journal of the American Veterinary Medical Association. 226(10) |
| ISSN: | 0003-1488 |
| Popis: | Objective—To assess whether the risk of development of hypothyroidism after treatment with iodine 131 (131I) was associated with the pattern of sodium pertechnetate Tc 99m activity in the thyroid gland detected via scintigraphy before treatment in cats with hyperthyroidism. Design—Retrospective study. Animals—165 cats. Procedure—Medical records of cats with hyperthyroidism that had been treated with 131I (from 1990 to 2002) and had undergone scintigraphy of the thyroid gland before treatment were reviewed; data regarding signalment, scintigraphic findings (classified as unilateral, bilateral-asymmetric, bilateral-symmetric, or multifocal patterns), serum total thyroxine (T4) concentrations before treatment and prior to hospital discharge, and 131I treatment were collected. A questionnaire was sent to each referring veterinarian to obtain additional data including whether the cats subsequently developed hypothyroidism (defined as serum total T4 concentration less than the lower reference limit ≥ 3 months after treatment). Results—50 of 165 (30.3%) 131I-treated cats developed hypothyroidism. Hypothyroidism developed in 39 of 109 cats with bilateral, 10 of 50 cats with unilateral, and 1 of 6 cats with multifocal scintigraphic patterns of their thyroid glands. Cats with a bilateral scintigraphic pattern were approximately 2 times as likely to develop hypothyroidism after 131I treatment than were cats with a unilateral scintigraphic pattern (hazard ratio, 2.1; 95% confidence interval, 1.04 to 4.2). Conclusions and Clinical Relevance—Cats with hyperthyroidism that have a bilateral scintigraphic pattern in the thyroid gland before 131I treatment appear to have a significantly higher risk of subsequently developing hypothyroidism, compared with cats with a unilateral scintigraphic pattern. (J Am Vet Med Assoc 2005;226:1671–1675) |
| Databáze: | OpenAIRE |
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