The National Brain Injury Rescue and Rehabilitation Study - a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms

Autor: William Duncan, Eddie Zant, Robert L Beckman, Kenneth P Stoller, B Robert Mozayeni, Tommy L Love
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Traumatic brain injury
medicine.medical_treatment
Neuroscience (miscellaneous)
Severity of Illness Index
Stress Disorders
Post-Traumatic

lcsh:RD78.3-87.3
Young Adult
03 medical and health sciences
0302 clinical medicine
mTBI
Brain Injuries
Traumatic

Outcome Assessment
Health Care

Concussion
medicine
Humans
030212 general & internal medicine
HBOT
Rehabilitation Study
Hyperbaric Oxygenation
Rehabilitation
Post-concussion syndrome
Post-Concussion Syndrome
business.industry
traumatic brain injury
PTSD
Mental Status and Dementia Tests
medicine.disease
Institutional review board
hyperbaric oxygen
post-concussion syndrome
post-traumatic stress disorder
21 st Century Cures Act
concussion
Clinical trial
Military Personnel
Anesthesiology and Pain Medicine
Rehabilitation Research
lcsh:Anesthesiology
Emergency medicine
Female
business
Neurocognitive
030217 neurology & neurosurgery
Research Article
21st Century Cures Act
Zdroj: Medical Gas Research, Vol 9, Iss 1, Pp 1-12 (2019)
Medical Gas Research
ISSN: 2045-9912
Popis: The National Brain Injury Rescue and Rehabilitation Project was established as a preliminary study to test the safety and practicality of multi-center hyperbaric oxygen administration for the post-concussive symptoms of chronic mild traumatic brain injury as a precursor to a pivotal, independent, multi-center, controlled clinical trial. This report presents the results for 32 subjects who completed a preliminary trial of hyperbaric oxygen several years before the passage of the 21 st Century Cures Act. This study anticipated the Act and its reassessment of clinical research. Subjects received 40-82 one-hour treatments at 1.5 atmospheres absolute 100% oxygen. Outcome measures included repeated self-assessment measures and automated neurocognitive tests. The subjects demonstrated improvement in 21 of 25 neurocognitive test measures observed. The objective neurocognitive test components showed improvement in 13 of 17 measures. Earlier administration of hyperbaric oxygen post injury, younger age at the time of injury and hyperbaric oxygen administration, military status, and increased number of hyperbaric oxygen administrations were characteristics associated with improved outcomes. There were no adverse events. Hyperbaric oxygen was found to be safe, inexpensive and worthy of clinical application in the 21 st Century model of facile data collection provided by recent research regulatory shifts in medicine. The study was approved by the ethics review committee of the Western Institutional Review Board (WIRB; Protocol #20090761).
Databáze: OpenAIRE
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