Prenatal Vitamin D Deficiency Induces an Early and More Severe Experimental Autoimmune Encephalomyelitis in the Second Generation
| Autor: | Adrian G. Barnett, Diana Andrea Fernandes De Abreu, Francois Feron, John J. McGrath, Darryl W. Eyles, Véréna Landel |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Vitamin Encephalomyelitis Autoimmune Experimental Season of birth Offspring multiple sclerosis Catalysis vitamin D deficiency Inorganic Chemistry lcsh:Chemistry Mice chemistry.chemical_compound Pregnancy medicine Vitamin D and neurology vitamin D experimental autoimmune encephalomyelitis Animals Humans transgenerational Physical and Theoretical Chemistry Molecular Biology Prenatal vitamins lcsh:QH301-705.5 Spectroscopy season of birth business.industry Brief Report Organic Chemistry Experimental autoimmune encephalomyelitis Parturition General Medicine deficiency Vitamin D Deficiency medicine.disease Pedigree Computer Science Applications Mice Inbred C57BL Pregnancy Complications chemistry lcsh:Biology (General) lcsh:QD1-999 Immunology Female Seasons business |
| Zdroj: | International Journal of Molecular Sciences, Vol 13, Iss 9, Pp 10911-10919 (2012) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | In a previous study, we demonstrated that mouse adult F1 offspring, exposed to a vitamin D deficiency during pregnancy, developed a less severe and delayed Experimental Autoimmune Encephalomyelitis (EAE), when compared with control offspring. We then wondered whether a similar response was observed in the subsequent generation. To answer this question, we assessed F2 females whose F1 parents (males or females) were vitamin D-deprived when developing in the uterus of F0 females. Unexpectedly, we observed that the vitamin D deficiency affecting the F0 pregnant mice induced a precocious and more severe EAE in the F2 generation. This paradoxical finding led us to assess its implications for the epidemiology of Multiple Sclerosis (MS) in humans. Using the REFGENSEP database for MS trios (the patient and his/her parents), we collected the parents’ dates of birth and assessed a potential season of birth effect that could potentially be indicative of the vitamin D status of the pregnant grandmothers. A trend for a reduced number of births in the Fall for the parents of MS patients was observed but statistical significance was not reached. Further well powered studies are warranted to validate the latter finding. |
| Databáze: | OpenAIRE |
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