Parathyroid function in uremic children during periods of renal insufficiency, hemodialysis, and transplantation
| Autor: | Allen W. Root, H. Jorge Baluarte, Gregory E. Duckett, Alan B. Gruskin |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment chemistry.chemical_element Parathyroid hormone Calcium Parathyroid Glands Renal Dialysis Internal medicine medicine Humans Renal osteodystrophy Child Uremia Clinical Trials as Topic Hyperparathyroidism Hyperplasia Hypocalcemia business.industry medicine.disease Kidney Transplantation Transplantation medicine.anatomical_structure Endocrinology chemistry Pediatrics Perinatology and Child Health Hypercalcemia Prednisolone Kidney Failure Chronic Parathyroid gland Hemodialysis business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | The Journal of Pediatrics. 89:755-762 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(76)80797-4 |
| Popis: | Function of the parathyroid gland was evaluated in children with renal insufficiency prior to and after initiation of hemodialysis, and again following renal transplantation. Serum levels of immunoreactive parathyroid hormone responded appropriately to increases or decreases of serum calcium concentrations in the three groups. Functional and histologic studies in the children with renal insufficiency demonstrated the cause of their elevated circulating levels of iPTH to be diffuse parathyroid hyperplasia. During hemodialysis, the serum concentration of calcium rose and that of iPTH decreased, when the calcium gradient between the dialysate and the blood favored movement of calcium into the body. During treatment with prednisolone (20 mg/kg intravenously) for reversal of renal transplant rejection, the serum concentration of calcium decreased and that of iPTH increased. These observations suggest that autonomy of the parathyroid gland rarely occurs in children with renal insufficiency, and that hemodialysis using a dialysate with a high concentration of calcium might assist in retarding the progression of renal osteodystrophy. Furthermore, if hyperparathyroidism contributes in part to growth failure in children with chronic renal disease, steroid-induced changes in cirulating iPTH following renal transplantation may inhibit growth. |
| Databáze: | OpenAIRE |
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