Relation of Neutrophil to Lymphocyte Ratio With the Presence and Severity of Stable Coronary Artery Disease
| Autor: | Yasemin Kaya, Turgay Isik, Selim Topcu, Ibrahim Halil Tanboga, Mustafa Kurt, Zeki Yüksel Günaydın, Serdar Sevimli, Ahmet Kaya |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Neutrophils Coronary Artery Disease Coronary artery disease Internal medicine medicine Humans Lymphocyte Count Lymphocytes Neutrophil to lymphocyte ratio Aged business.industry Stroke Volume Hematology General Medicine Middle Aged medicine.disease Immunology Cardiology Population study Female Inflammation Mediators business Biomarkers Glomerular Filtration Rate |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis. 20:473-477 |
| ISSN: | 1938-2723 1076-0296 |
| Popis: | Objectives: We examined the association between neutrophil to lymphocyte ratio (NLR) and the complexity of coronary artery disease assessed by SYNTAX score (SS). Methods: The study population included patients with chest pain who had undergone coronary angiography for stable angina pectoris. Patients were classified depending on whether the SS was 0 or SS > 0. Results: Left ventricular ejection fraction, estimated glomerular filtration rate, and NLR were found to be the independent predictors of high SS in multivariate analysis. The area under the receiver–operating curve of NLR was 0.72 (0.65-0.80, P < .001) for predicting high SS. The optimal cutoff value of NLR to predict high SS was 2.7 (sensitivity of 72% and a specificity of 61%). There was a significant correlation between NLR ratio and continuous SS ( r = .552, P < .001). Conclusion: The NLR is a readily measurable systemic inflammatory marker and is associated with both the presence and the complexity of coronary artery disease. |
| Databáze: | OpenAIRE |
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