Evaluation of silver nanoparticles for the prevention of SARS-CoV-2 infection in health workers: In vitro and in vivo

Autor: Ismael Plascencia-López, Alberto Reyes-Escamilla, Nina Bogdanchikova, Belén Borrego, Horacio Almanza-Reyes, Sandra Moreno, Daniel Valencia-Manzo, Alejandro Brun, Martha Alvarado-Vera, Leslie Patron-Romero, Alexey Pestryakov
Jazyk: angličtina
Rok vydání: 2021
Předmět:
RNA viruses
Male
Viral Diseases
Pulmonology
Coronaviruses
Mouthwashes
Metal Nanoparticles
Health personnel
Medical Conditions
Pandemic
Health care
Chlorocebus aethiops
Nanotechnology
Medical Personnel
Nose
Pathology and laboratory medicine
Vaccines
Multidisciplinary
Incidence (epidemiology)
Medical microbiology
Middle Aged
Chemistry
Professions
medicine.anatomical_structure
Infectious Diseases
Viruses
Physical Sciences
Medicine
Engineering and Technology
Female
SARS CoV 2
Pathogens
Anatomy
Research Article
Chemical Elements
Adult
medicine.medical_specialty
Silver
SARS coronavirus
Infectious Disease Control
Adolescent
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Science
Health Personnel
Microbiology
Respiratory Disorders
In vivo
Internal medicine
Virology
medicine
Animals
Humans
Mexico
Vero Cells
Aged
Medicine and health sciences
Biology and life sciences
business.industry
SARS-CoV-2
Organisms
Viral pathogens
Outbreak
COVID-19
Covid 19
Viral Vaccines
Microbial pathogens
body regions
Face
Respiratory Infections
People and Places
Nanoparticles
Population Groupings
business
Head
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0256401 (2021)
ISSN: 1932-6203
Popis: SARS-CoV-2 infection in hospital areas is of a particular concern, since the close interaction between health care personnel and patients diagnosed with COVID-19, which allows virus to be easily spread between them and subsequently to their families and communities. Preventing SARS-CoV-2 infection among healthcare personnel is essential to reduce the frequency of infections and outbreaks during the pandemic considering that they work in high-risk areas. In this research, silver nanoparticles (AgNPs) were tested in vitro and shown to have an inhibitory effect on SARS-CoV-2 infection in cultured cells. Subsequently, we assess the effects of mouthwash and nose rinse with ARGOVIT® silver nanoparticles (AgNPs), in the prevention of SARS-CoV-2 contagion in health workers consider as high-risk group of acquiring the infection in the General Tijuana Hospital, Mexico, a hospital for the exclusive recruitment of patients diagnosed with COVID-19. We present a prospective randomized study of 231 participants that was carried out for 9 weeks (during the declaration of a pandemic). The "experimental" group was instructed to do mouthwash and nose rinse with the AgNPs solution; the "control" group was instructed to do mouthwashes and nose rinse in a conventional way. The incidence of SARS-CoV-2 infection was significantly lower in the "experimental" group (two participants of 114, 1.8%) compared to the "control" group (thirty-three participants of 117, 28.2%), with an 84.8% efficiency. We conclude that the mouth and nasal rinse with AgNPs helps in the prevention of SARS-CoV-2 infection in health personnel who are exposed to patients diagnosed with COVID-19.
Databáze: OpenAIRE
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