The bisphenol a induced oxidative stress in non-alcoholic fatty liver disease male patients: A clinical strategy to antagonize the progression of the disease
| Autor: | Mario Masarone, Alessandro Federico, Filomena Morisco, Mario Romeo, Antonietta Gerarda Gravina, Concetta Tuccillo, Carmelina Loguercio, Sonia Errico, Marcello Persico, Nadia Diano, Paola Stiuso, Marcello Dallio |
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| Přispěvatelé: | Federico, A., Dallio, M., Gravina, A. G., Diano, N., Errico, S., Masarone, M., Romeo, M., Tuccillo, C., Stiuso, P., Morisco, F., Persico, M., Loguercio, C. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty endocrine system Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Cancer biology lcsh:Medicine medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine Insulin resistance Phenols Internal medicine Vitamin D and neurology TBARS Humans Medicine Obesity Benzhydryl Compounds Benzhydryl Compound urogenital system business.industry Vitamin E lcsh:R Fatty liver Public Health Environmental and Occupational Health Oxidative Stre Middle Aged medicine.disease Oxidative Stress Endocrinology Italy Liver 030220 oncology & carcinogenesis Homeostatic model assessment 030211 gastroenterology & hepatology business Oxidative stress hormones hormone substitutes and hormone antagonists Human Non-alcoholic fatty liver disease |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 17 Issue 10 International Journal of Environmental Research and Public Health, Vol 17, Iss 3369, p 3369 (2020) |
| Popis: | Introduction: Bisphenol A (BPA) exposure has been correlated to non-alcoholic fatty liver disease (NAFLD) development and progression. We investigated, in a clinical model, the effects of the administration of 303 mg of silybin phospholipids complex, 10 g of vitamin D, and 15 mg of vitamin E (RealSIL, 100D, IBI-Lorenzini, Aprilia, Italy) in male NAFLD patients exposed to BPA on metabolic, hormonal, and oxidative stress-related parameters. Methods: We enrolled 32 male patients with histologic diagnosis of NAFLD and treated them with Realsil 100D twice a day for six months. We performed at baseline clinical, biochemical, and food consumption assessments as well as the evaluation of physical exercise, thiobarbituric acid reactive substances (TBARS), plasmatic and urinary BPA and estrogen levels. The results obtained were compared with those of healthy control subjects and, in the NAFLD group, between baseline and the end of treatment. Results: A direct proportionality between TBARS levels and BPA exposure was shown (p < 0.0001). The therapy determined a reduction of TBARS levels (p = 0.011), an improvement of alanine aminotransferase, aspartate aminotransferase, insulinemia, homeostatic model assessment insulin resistance, C reactive protein, tumor necrosis factor alpha (p < 0.05), an increase of conjugated BPA urine amount, and a reduction of its free form (p < 0.0001 p = 0.0002). Moreover, the therapy caused an increase of plasmatic levels of the native form of estrogens (p = 0.03). Conclusions: We highlighted the potential role of BPA in estrogen oxidation and oxidative stress in NAFLD patients. The use of Realsil 100D could contribute to fast BPA detoxification and to improve cellular antioxidant power, defending the integrity of biological estrogen-dependent pathways. |
| Databáze: | OpenAIRE |
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