Antibody-dependent Cytotoxicity of Human Platelets Against Trypanosoma Cruzi

Autor:	R. P. Laguens, J. G. Chambo, O. M. Spinelli, P. M. Cabeza Meckert
Rok vydání:	1991
Předmět:	biology Hematology General Medicine Immunoglobulin E biology.organism_classification parasitic diseases Immunology biology.protein Cytotoxic T cell Parasite hosting Platelet Antibody South American trypanosomiasis Cytotoxicity Trypanosoma cruzi
Zdroj:	Platelets. 2:89-92
ISSN:	1369-1635 0953-7104
Popis:	Human platelets in the presence of sera from humans with chronic Chagas' disease display cytotoxic activity against Trypanosoma cruzi (T. cruzi) trypomastigotes. Adsorption of IgE from those sera decrease the cytotoxic effect and IgG purified from the same sera revealed a cytotoxic action similar to the whole sera. Morphological studies suggest that chagasic serum promotes adhesion between parasites and platelets. On the basis of these results it is postulated that platelets may represent a defensive mechanism in South American trypanosomiasis by killing circulating forms of the parasite and that both IgG and IgE are relevant for that action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa27e3c1c4c63ff892449de9b2388d7 https://doi.org/10.3109/09537109109113693 Zobrazit plný text záznamu