Awareness and documentation of the teratogenic effects of valproate among women of child-bearing potential
| Autor: | Deirdre Mulryan, Colm McDonald, Sabina Feeney, Anna McIntyre, B. Hallahan |
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| Rok vydání: | 2018 |
| Předmět: |
Clinical interview
medicine.medical_specialty Valproate business.industry Context (language use) folate Mental health Original Papers 030227 psychiatry Mental health service 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Documentation Folic acid medicine Child bearing teratogenesis Psychiatry Adverse effect business 030217 neurology & neurosurgery |
| Zdroj: | BJPsych Bulletin |
| ISSN: | 2056-4694 |
| Popis: | Aims and methodWe aimed to evaluate clinical note documentation of valproate prescribing and establish the level of knowledge among women of child-bearing potential regarding valproate-associated adverse effects, including teratogenesis, in a regional Irish mental health service.ResultsOf the 42 women prescribed sodium valproate, 21.4% (n = 9) had some documentation in relation to associated risks and 33.3% (n = 14) described an awareness of these risks from consultation with their treating mental health team. On clinical interview, 9.5% (n = 4) of individuals with clear documentation of the risks of teratogenesis described no such awareness. Augmentation with lithium was associated with greater awareness of the teratogenic risks of valproate (P = 0.011).Clinical implicationsA clear description of the teratogenic risks of valproate and potential management strategies, including advice regarding contraception and supplementation with folic acid, should be clearly documented and provided repeatedly and in context to all women of child-bearing age who are prescribed valproate.Declaration of interestNone. |
| Databáze: | OpenAIRE |
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