Sleep spindles and k-complex activities are decreased in spinocerebellar ataxia type 2: relationship to memory and motor performances
| Autor: | Roberto Rodríguez-Labrada, Arnoy Peña-Acosta, Inca Tuin, Ursula Voss, Luis Velázquez-Pérez, Jacqueline Medrano-Montero, Georg Auburger, Yanetza González-Zaldivar, Yaimeé Vázquez-Mojena, Nalia Canales-Ochoa, Annelié Estupiñán-Rodríguez, Lourdes Galicia-Polo |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Sleep Wake Disorders medicine.medical_specialty Ataxia Polysomnography Sleep REM Sleep spindle Audiology Motor Activity Neuropsychological Tests 03 medical and health sciences 0302 clinical medicine Memory Restless Legs Syndrome Neuroplasticity medicine Humans Spinocerebellar Ataxias business.industry Neuropsychology Electroencephalography General Medicine medicine.disease Sleep in non-human animals 030228 respiratory system Spinocerebellar ataxia Female Sleep Stages medicine.symptom Verbal memory K-complex business 030217 neurology & neurosurgery |
| Zdroj: | Sleep Medicine. 64:S324 |
| ISSN: | 1389-9457 |
| Popis: | Background Sleep spindles and K-complexes are electroencephalographic hallmarks of non-rapid eye movement (non-REM) sleep that provide valuable information into brain functioning, plasticity and sleep functions in normal and pathological conditions. However, they have not been systematically investigated in spinocerebellar ataxias (SCA). To close this gap, the current study was carried out to quantify sleep spindles and K-complexes in SCA2 and to assess their relationship with clinical and molecular measures, as well as with memory and attention/executive functioning. Methods In this study, 20 SCA2 patients, 20 preclinical carriers and 20 healthy controls underwent whole-night polysomnographic (PSG) recordings as well as sleep interviews, ataxia scoring and neuropsychological assessments. Sleep spindles and K-complexes were automatically detected during non-REM sleep stage 2 (N2). Their densities were evaluated as events/minute. Results Compared to controls, sleep spindle density was significantly reduced in SCA2 patients and preclinical subjects. By contrast, K-complex density was specifically and significantly decreased only in SCA2 patients. Reduced spindle activity correlated with measures of verbal memory, whereas reduced K-complex activity correlated with age, ataxia severity and N3 sleep percentage in SCA2 patients. Conclusions Findings document an impairment of N2 sleep microstructure in SCA2 already in prodromal stages, suggesting an early involvement of thalamo-cortical and/or cortical circuits underlying the generation of sleep spindles and K-complexes. Thus, sleep spindle density may serve as useful biomarker for deficits of neural plasticity mechanisms underlying verbal memory alterations in patients. It may also serve as promising outcome measure in further therapeutical trials targeting memory decline in SCA2. With regard to K-complexes, they have potential usefulness as marker of sleep protection. |
| Databáze: | OpenAIRE |
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