Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats
| Autor: | Kiyofumi Yamada, Kazuyuki Fuji, Toshitaka Nabeshima, Tsutomu Kameyama |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Central nervous system Glutamate decarboxylase Pharmacology Biology Hippocampal formation Hippocampus Choline O-Acetyltransferase Injections chemistry.chemical_compound medicine Animals Neurotoxin Injections Intraventricular Cerebral Cortex Glutamate Decarboxylase General Neuroscience Neurotoxicity Brain Rats Inbred Strains Hemicholinium 3 Quinolinic Acid medicine.disease Choline acetyltransferase Corpus Striatum Rats Quinolinic Acids medicine.anatomical_structure chemistry Ventricle Anesthesia Dizocilpine Maleate Nervous System Diseases Quinolinic acid |
| Zdroj: | Neuroscience Letters. 118:128-131 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(90)90265-b |
| Popis: | Acute intrastriatal injection of quinolinic acid (QA) caused a significant reduction of choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities as well as a decrease of the specific binding of [3H]hemicholinium-3. Pretreatment with MK-801 completely blocked the QA-induced neurotoxicity. Continuous infusion of QA into the lateral ventricle resulted in a reduction of hippocampal and cortical ChAT activities while GAD activities were unchanged. These results suggest that continuous infusion of QA into the lateral ventricle could be a useful technique for the study of chronic neurodegenerative diseases including Alzheimer's disease. |
| Databáze: | OpenAIRE |
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