Formulation and evaluation of injectable in situ forming microparticles for sustained delivery of lornoxicam
| Autor: | Soad A. Yehia, Mary Yosry Aziz, Sally A. Abdel-Halim |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Materials science Scanning electron microscope Inherent viscosity Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy 03 medical and health sciences Piroxicam 0302 clinical medicine Drug Delivery Systems Pharmacokinetics Lornoxicam Drug Discovery medicine Animals Particle Size Pharmacology chemistry.chemical_classification Chromatography Viscosity Organic Chemistry Factorial experiment Polymer 021001 nanoscience & nanotechnology Biodegradable polymer Surgery Drug Liberation chemistry Nanoparticles Emulsions Particle size Rabbits 0210 nano-technology medicine.drug |
| Zdroj: | Drug development and industrial pharmacy. 43(2) |
| ISSN: | 1520-5762 |
| Popis: | The objective of this study is to formulate biodegradable in situ microparticles (ISM) containing lornoxicam for post-operative and arthritic pain management. ISM emulsions were prepared according to 25 full factorial experimental design to investigate the influence of formulation variables on the release profile of the drug. The independent variables studied are the polymer type, polymer inherent viscosity, polymer concentration, oil type and polymer:oil ratio. In vitro drug release, microscopical examination, particle size determination and syringeability measurement were selected as dependent variables. The effect of γ-sterilization on the prepared formulae was also examined. The prepared formulae showed extended drug release over two weeks, and flow time below 5 s/ml. Scanning electron microscope revealed that the prepared microparticles were spherical in shape, with diameter ranging from 3.45 to 22.78 µm. In vivo pharmacokinetic evaluation of two selected optimum formulations in rabbits showe... |
| Databáze: | OpenAIRE |
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