USEFULNESS OF PROSTATE SPECIFIC ANTIGEN/^|^gamma;-SEMINOPROTEIN RATIO FOR DIAGNOSIS OF PROSTATE CANCER
| Autor: | Tatsuya Chikaraishi, Nobuo Oohashi, Tetsuo Hirano, Takayoshi Demura, Yoshihiko Watarai, Masaki Togashi |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Oncology PCA3 medicine.medical_specialty Urology Adenocarcinoma urologic and male genital diseases Muscle hypertrophy Prostate cancer Antigens Neoplasm Prostate Internal medicine Biomarkers Tumor medicine Humans In patient Gamma seminoprotein business.industry Seminal Plasma Proteins Prostatic Neoplasms Prostatic Secretory Proteins Proteins Prostate-Specific Antigen Serum concentration medicine.disease Prostate-specific antigen medicine.anatomical_structure business |
| Zdroj: | The Japanese Journal of Urology. 84:1046-1053 |
| ISSN: | 1884-7110 0021-5287 |
| DOI: | 10.5980/jpnjurol1989.84.1046 |
| Popis: | Prostate specific antigen (PSA) and gamma-seminoprotein (gamma-Sm) are used as tumor markers of the prostate cancer. However, the serum concentrations of PSA and gamma-Sm are frequently increased in patients with benign prostatic hypertrophy (BPH). We measured the ratio of serum PSA to gamma-Sm concentration (P/S ratio), and evaluated its usefulness for diagnosis of prostate cancers. Between April 1988 and July 1992, 162 men underwent prostatic biopsy and/or TUR-P, and were diagnosed pathologically. Of 162 patients, 112 were diagnosed as BPH and 50 were diagnosed as prostate cancer. Of 24 patients with serum PSA level of20 ng/ml, 23 (95.8%) were prostate cancer, while, of 79 patients with serum PSA level of 3.0-20 ng/ml, 23 (29.1%) were prostate cancer. The sensitivity and the specificity for PSA were 92.0% and 49.1%, respectively. Of 85 patients with serum gamma-Sm level of4.0 ng/ml, 30 (35.3%) were prostate cancer. The sensitivity and the specificity for gamma-Sm were 60.0% and 50.9%, respectively. A mean +/- SD of P/S ratio in 112 patients with BPH was 0.954 +/- 0.591. While, the mean +/- SD of P/S ratio was 16.295 +/- 58.584 in all prostate cancer patients, and 2.031 +/- 0.654 in 27 prostate cancer patients with serum PSA level ofor = 20 ng/ml. P/S Ratio in prostate cancer patients with serum PSA ofor = 20 ng/ml as well as in all prostate cancer patients were significantly higher than P/S Ratio of BPH patients (p0.0001). Of 55 patients with P/S Ratio ofor = 1.50, 45 (81.8%) were prostate cancer and 10 (18.2%) were BPH. While, of 107 patients with P/S Ratio of1.50, 102 (95.3%) were BPH and 5 (4.7%) were prostate cancer. The sensitivity and the specificity for P/S Ratio were 90.0% and 91.1%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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