Hsa_circ_0072309 inhibits proliferation and invasion of glioblastoma
| Autor: | Qian Sun, Jian Yang, Gang Deng, Shenqi Zhang, Yang Xu, Yuan Fan'en, Huikai Zhang, Baohui Liu, Junhui Liu, Qianxue Chen |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Regulator urologic and male genital diseases Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Expression pattern Hsp27 Cell Movement Cell Line Tumor medicine Humans Neoplasm Invasiveness Cytoskeleton Cell Proliferation biology urogenital system Chemistry Cell growth Brain Neoplasms Cell Biology RNA Circular medicine.disease female genital diseases and pregnancy complications nervous system diseases Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Cancer research Glioblastoma Function (biology) |
| Zdroj: | Pathology, research and practice. 222 |
| ISSN: | 1618-0631 |
| Popis: | Increasing literature reported that circRNAs play vital roles in the occurrence and progression of GBM and regulate GBM cell proliferation, metastases, and chemosensitivity. However, the expression pattern and function of circRNAs in GBM still need further studies. In our work, hsa_circ_0072309 was remarkably downregulated in GBM. Hsa_circ_0072309 inhibits proliferation and invasion of glioblastoma and affects cytoskeletal of GBM cells. Moreover, we found that the function of hsa_circ_0,072,309 in GBM was associated with HSP27, which was reported to be an important regulator of cell proliferation, invasion and cytoskeletal. Our study provides a novel view of hsa_circ_0072309 in GBM cell proliferation and invasion, indicating that hsa_circ_0072309 may act as a potential therapeutic target for GBM comprehensive treatment. |
| Databáze: | OpenAIRE |
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