Trypanocidal constituents in plants 5. Evaluation of some Mexican plants for their trypanocidal activity and active constituents in the seeds of Persea americana
| Autor: | Hiroshige Akahane, Masafumi Okawa, Fumiko Abe, Ricardo Reyes-Chilpa, Shinya Nagafuji, Tetsuya Ogura, Junei Kinjo, Miguel Angel Martinez-Alfaro |
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| Rok vydání: | 2005 |
| Předmět: |
Chagas disease
Persea Screening test Trypanosoma cruzi Drug Evaluation Preclinical Pharmaceutical Science Moderate activity Cell Line Cell Line Tumor parasitic diseases Botany medicine Animals Humans Medicinal plants Pharmacology biology Traditional medicine Protozoan diseases Spectrum Analysis General Medicine biology.organism_classification medicine.disease Macaca mulatta Trypanocidal Agents Seeds Spectrum analysis |
| Zdroj: | Biologicalpharmaceutical bulletin. 28(7) |
| ISSN: | 0918-6158 |
| Popis: | Crude extracts of Mexican medicinal plants were screened for trypanocidal activity against Trypanosoma cruzi, which is the etiological agent for Chagas' disease, one of the most serious protozoan diseases in Latin America. There were 71 kinds of methanolic and other organic extracts from 65 plants, which were newly examined by a preliminary screening test to observe immobilization of epimastigotes and trypomastigotes of T. cruzi in vitro. The MeOH extract of seeds of Persea americana (avocado) showed moderate activity against epimastigotes. In order to identify the principal compounds for the activity, the MeOH extract was subjected to bioassay-guided fractionation. From the active fractions, six 1,2,4-trihydroxyheptadecane derivatives and two 1,2,4-trihydroxynonadecane derivatives including a new one were isolated. These compounds showed moderate activity against epimastigotes and trypomastigotes. |
| Databáze: | OpenAIRE |
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