Antimicrobial peptides signal need for sleep from peripheral wounds to the nervous system
| Autor: | Henrik Bringmann, Jonathan J. Ewbank, Florentin Masurat, Nathalie Pujol, Marina P. Sinner |
|---|---|
| Přispěvatelé: | Philipps Universität Marburg = Philipps University of Marburg, Max-Planck-Institut für Biophysikalische Chemie - Max Planck Institute for Biophysical Chemistry [Göttingen], Max-Planck-Gesellschaft, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Turing Centre for Living Systems [Marseille] (TCLS), Philipps Universität Marburg, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Turing Centre for Living Systems, Marseille, France, pujol, nathalie |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nervous system
0303 health sciences Innate immune system integumentary system Mechanism (biology) [SDV]Life Sciences [q-bio] Antimicrobial peptides Biology Sleep in non-human animals Peripheral Cell biology [SDV] Life Sciences [q-bio] 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine Neuron 030217 neurology & neurosurgery Function (biology) 030304 developmental biology |
| Popis: | Wounding triggers a protective innate immune response that includes the production of antimicrobial peptides and increased sleep. Little is known, however, about how peripheral wounds signal need for sleep to the nervous system. We found that duringC. eleganslarval molting, a tolloid/BMP-1-like protein promotes sleep through an epidermal innate immune pathway and the expression of more than a dozen antimicrobial peptide (AMP) genes. In the adult, epidermal injury activates innate immunity and turns up AMP production to trigger sleep. We show for one AMP, NLP-29, that it acts through the neuropeptide receptor NPR-12 in neurons that depolarize the sleep-active RIS neuron to induce sleep. Sleep in turn increases the chance of surviving injury. Thus, we found a novel mechanism by which peripheral wounds signal to the nervous system to increase protective sleep. Such a long-range somnogen signaling function of AMPs might also boost sleep in other animals including humans.Highlights- Gain-of-function mutation in the tolloid/BMP-1-like NAS-38 protein increases sleep- NAS-38 activates innate immunity pathways to ramp up STAT-dependent antimicrobial peptide (AMP) expression- Wounding increases sleep through the innate immune response and AMPs- Antimicrobial peptides are long-range somnogens that act through neuronal neuropeptide receptors to depolarize a sleep-active neuron- Sleep increases the chance to survive injuryGraphical Abstract |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|