Does fish oil protect renal function in cyclosporin-treated psoriasis patients?
| Autor: | M. J. Korstanje, R. F. H. J. Hulsmans, T. J. Stoof, H. J. G. Bilo, Th. M. Starink, A. J. M. Donker |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Renal function Cyclosporins Pilot Projects Kidney Function Tests Fish Oils Cyclosporin a Psoriasis Internal medicine Internal Medicine Medicine Humans business.industry Effective renal plasma flow Fish oil medicine.disease Eicosapentaenoic acid Endocrinology Docosahexaenoic acid Toxicity Fatty Acids Unsaturated lipids (amino acids peptides and proteins) Female Kidney Diseases business |
| Zdroj: | Journal of internal medicine. 226(6) |
| ISSN: | 0954-6820 |
| Popis: | In order to study the influence of fish oil on CyA-induced renal dysfunction, 13 patients with psoriasis (CyA group) received cyclosporin A (CyA) alone, and seven patients (CyA/EPA + DHA group) received a combination of cyclosporin A and fish oil (6g eicosapentaenoic acid, C20:5 omega-3, and docosahexaenoic acid, C22:6 omega-3, daily) for 3 months. The glomerular filtration rate fell by 18.0 +/- 9.6% in the CyA group compared with 8.7 +/- 6.8% in the CyA/EPA + DHA group (mean +/- SD, P less than 0.05). The effective renal plasma flow fell by 10.6 +/- 8.9% in the CyA group and did not change in the CyA/EPA + DHA group (P less than 0.05). The calculated total renal vascular resistance increased by 19.8 +/- 14.5% in the CyA group and did not change in the CyA/EPA + DHA group (P less than 0.01). The results of this pilot study suggest that fish oil can reduce CyA-associated renal dysfunction in psoriasis patients. |
| Databáze: | OpenAIRE |
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