Integrin Subunit beta 8 (ITGB8) Upregulation Is an Independent Predictor of Unfavorable Survival of High-Grade Serous Ovarian Carcinoma Patients
| Autor: | Jing He, Yan Liu, Hongwei Zhang, Lixia Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Integrins Integrin beta Chains Kaplan-Meier Estimate Carcinoma Ovarian Epithelial Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Lab/In Vitro Research Ovarian carcinoma Biomarkers Tumor Medicine Humans ITGB8 Beta (finance) Aged Ovarian Neoplasms business.industry Proportional hazards model Cancer General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Cystadenocarcinoma Serous Up-Regulation Serous fluid 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Female Neoplasm Recurrence Local business Ovarian cancer Transcriptome |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 1234-1010 |
| Popis: | BACKGROUND ITGB8 encodes a β subunit of integrin (integrin β8), which is upregulated in some types of cancer. In the current study, we examined the expression profile of ITGB8 in serous ovarian cancer (SOVC) and investigated its potential as an independent prognostic indicator for overall survival (OS) and recurrence-free survival (RFS) in high-grade SOVC. MATERIAL AND METHODS A secondary study was conducted based on genomic and survival data in large online databases, including the Gene Expression Omnibus (GEO), the Human Protein Atlas (HPA), and the Cancer Genome Atlas-Ovarian cancer (TCGA-OV). Kaplan-Meier curves were generated to evaluate the association between ITGB8 expression and OS/RFS. Univariate and multivariate analysis were performed with the Cox regression model. RESULTS ITGB8 was significantly upregulated in ovarian cancer tissues compared to that in normal ovary tissues. High-grade SOVC patients with high ITGB8 expression had significantly shorter OS and RFS compared to their low-expression counterparts. Increased ITGB8 expression might be an independent prognostic indicator of unfavorable OS (HR: 1.424, 95%CI: 1.228-1.653, p |
| Databáze: | OpenAIRE |
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