Neuropsychiatric symptoms in systemic lupus erythematosus: impact on quality of life
| Autor: | Twj Huizinga, G. M. Steup-Beekman, J Hoekman, L.J.J. Beaart-van de Voorde, Ad A. Kaptein, R C Monahan, César Magro-Checa |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty SF-36 SLE 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) Rheumatology medicine Humans Lupus Erythematosus Systemic In patient 030212 general & internal medicine skin and connective tissue diseases Netherlands 030203 arthritis & rheumatology business.industry Lupus Vasculitis Central Nervous System Middle Aged Health Surveys quality of life Papers Physical therapy neuropsychiatric symptoms Female business NPSLE Follow-Up Studies |
| Zdroj: | Lupus Lupus, 26(12), 1252-1259 Lupus, 17 |
| Popis: | Objective Assess quality of life in patients with systemic lupus erythematosus (SLE) presenting with neuropsychiatric symptoms (neuropsychiatric SLE, NPSLE). Methods Quality of life was assessed using the Short-Form 36 item Health Survey (SF-36) in patients visiting the Leiden NPSLE clinic at baseline and at follow-up. SF-36 subscales and summary scores were calculated and compared with quality of life of the general Dutch population and patients with other chronic diseases. Results At baseline, quality of life was assessed in 248 SLE patients, of whom 98 had NPSLE (39.7%). Follow-up data were available for 104 patients (42%), of whom 64 had NPSLE (61.5%). SLE patients presenting neuropsychiatric symptoms showed a significantly reduced quality of life in all subscales of the SF-36. Quality of life at follow-up showed a significant improvement in physical functioning role ( p = 0.001), social functioning ( p = 0.007), vitality ( p = 0.023), mental health ( p = 0.014) and mental component score ( p = 0.042) in patients with neuropsychiatric symptoms not attributed to SLE, but no significant improvement was seen in patients with NPSLE. Conclusion Quality of life is significantly reduced in patients with SLE presenting neuropsychiatric symptoms compared with the general population and patients with other chronic diseases. Quality of life remains considerably impaired at follow-up. Our results illustrate the need for biopsychosocial care in patients with SLE and neuropsychiatric symptoms. |
| Databáze: | OpenAIRE |
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