Papillary thyroid microcarcinoma (PTMC): Prognostic factors, management and outcome in 403 patients

Autor: L. Rampin, C Pagetta, Isabella Merante Boschin, Maria Rosa Pelizzo, Andrea Piotto, Antonio Toniato, Domenico Rubello, Paolo Bernante
Rok vydání: 2006
Předmět:
Zdroj: European Journal of Surgical Oncology (EJSO). 32:1144-1148
ISSN: 0748-7983
DOI: 10.1016/j.ejso.2006.07.001
Popis: Aim To investigate an “optimal” therapeutic management of patients with papillary thyroid microcarcinoma (PTMC). Methods We evaluated a group of 403 consecutive patients affected by PTMC operated on by the same surgeon. Prognostic factors were evaluated by uni- and multivariate statistical analysis. Results After a mean follow-up of 8.5 years, 372 patients were living without disease (undetectable serum thyroglobulin levels), 24 patients were living with disease (increased serum thyroglobulin levels), 6 patients were deceased due to causes different from thyroid cancer, and 1 patient was deceased due to metastatic thyroid cancer. No statistically significant prognostic factor was found at uni- and multivariate analysis. However, it is worth noting that in patients with a larger primary tumour (size ≥ 5 mm) and treated by partial thyroidectomy alone, the prevalence of recurrent disease was higher than in patients treated by total thyroidectomy and 131 I administration. Conclusion It appears reasonable to perform total thyroidectomy (possibly associated with central compartment node dissection), 131 I whole body scan (followed by 131 I therapy when necessary) and TSH-suppressive hormonal therapy in patients with PTMC.
Databáze: OpenAIRE
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