Langerhans cell responses to ultraviolet B radiation
| Autor: | Toshiyuki Kitajima, Akira Takashima |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Programmed cell death
Cell signaling Langerhans cell integumentary system Ultraviolet Rays Chemistry DNA damage Macrophage Colony-Stimulating Factor Cell Differentiation Dermatology medicine.disease Biochemistry Cell Line Cell biology medicine.anatomical_structure Apoptosis Cell surface receptor Langerhans Cells medicine Animals Sunburn Molecular Biology Transcription factor Skin |
| Zdroj: | Journal of Dermatological Science. 19:153-160 |
| ISSN: | 0923-1811 |
| DOI: | 10.1016/s0923-1811(98)00075-9 |
| Popis: | Skin exposure to solar radiation induces a series of characteristic changes, from the acute sunburn reaction to the development of pre-malignant and malignant tumors. The spectra of radiation within the ultraviolet B (UVB) light range (from 290 to 320 nm in wavelength) appear to cause most of the deleterious effects of solar radiation. Immunological influences of UVB radiation have been studied by many investigators under rather diverse hypotheses concerning the identity of chromophores and mechanisms of action [1,2]. For example, plasma membrane-associated molecules, trans-urocanic acid, and DNA have been postulated as relevant chromophores [3–5]. Generation of reactive oxygen species, activation of selected transcription factors and signaling molecules, multimerization of cell surface receptors, and DNA damage have been considered to be the primary and causative molecular event inducible by UVB radiation [4–7]. UVB radiation has been shown to alter many immunological attributes in the skin, including the production of cytokines, expression of various surface molecules, and cell death by apoptotic mechanisms in keratinocytes, fibroblasts, endothelial cells, and Langerhans cells (LC) [8–12]. In this review article, we will overview the recent progress in our understanding of the immunological influences of UVB radiation on skin, focusing on its impact on LC, the major antigen resenting cells in the skin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect